Abstract

Cikrt, M., and Tichý, M. (1974).British Journal of Industrial Medicine,31, 134-139. Excretion of cadmium through bile and intestinal wall in rats. The excretion of Cd²⁺ through the bile and intestinal wall after intravenous administration of CdCl₂ in non-toxic doses (67, 90, and 120 μg of Cd²⁺ per rat) was studied in rats. The cumulative biliary excretion reached 24 hours after administration of the 67 μg dose was 0·83%, after 90 μg 1·18%, and after the 120 μg dose 5·68% of the amount given. The highest excretion rate of Cd²⁺ was detected between 15 and 30 minutes after administration. There was no difference in the excretion through intestinal wall between the 67 and 120 μg doses of Cd²⁺ per rat. The mean amount of cadmium found in the contents of the entire gastrointestinal tract and faeces was 5·5% of the administered dose. Using polyacrylamide gel disc electrophoresis it was found that Cd²⁺ is bound with at least two different components of the rat bile.