Article Text

Download PDFPDF
The Action Exerted by Certain Pneumoconiotic Factors upon the Acid Mucopolysaccharide Contents of Pulmonary Macrophages
  1. N. Gh. Lupu,
  2. Doina Velican,
  3. C. Velican,
  4. V. Olinescu
  1. Therapeutics Institute of the Academy of the Rumanian People's Republic, Bucharest


    Experimental inhalations of silicon dioxide and tobacco smoke cause a gradual increase in the number of pulmonary macrophages containing metachromatic material within the nucleus and cytoplasm, and they may assume the appearance of mast cells. Many pulmonary macrophages containing metachromatic material were found in anthracotic human lungs.

    Histochemical techniques identify this material as acid mucopolysaccharides. After a more prolonged action of pneumoconiotic substances, mucopolysaccharides disappear after hyaluronidase extraction.

    On the basis of these findings the increased amount of acid mucopolysaccharides in the connective interstices of the lung during the phase preceding the onset of fibrous lesions is explained by the prolonged irritative action of pneumoconiotic substances, which are believed to determine hypersecretion of acid mucopolysaccharides by the pulmonary macrophages.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.