Oxidative stress and regulation of glutathione in lung inflammation

I Rahman, W MacNee - European Respiratory Journal, 2000 - Eur Respiratory Soc
Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant
imbalance, a major cause of cell damage. The development of an oxidant/antioxidant …

Outcomes for COPD pharmacological trials: from lung function to biomarkers

M Cazzola, W MacNee, FJ Martinez… - European respiratory …, 2008 - Eur Respiratory Soc
The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …

Adverse cardiovascular effects of air pollution

…, PW Hadoke, NA Boon, W MacNee… - Nature clinical practice …, 2009 - nature.com
Air pollution is increasingly recognized as an important and modifiable determinant of
cardiovascular disease in urban communities. Acute exposure has been linked to a range of …

Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper

BR Celli, W MacNee, A Agusti… - European …, 2004 - Eur Respiratory Soc
Background The Standards for the Diagnosis and Treatment of Patients with COPD
document 2004 updates the position papers on chronic obstructive pulmonary disease (COPD) …

Particulate air pollution and acute health effects

A Seaton, D Godden, W MacNee, K Donaldson - The lancet, 1995 - Elsevier
Epidemiological studies have consistently shown an association between particulate air
pollution and not only exacerbations of illness in people with respiratory disease but also rises …

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

…, A Seaton, V Stone, S Brown, W MacNee… - Nature …, 2008 - nature.com
Carbon nanotubes 1 have distinctive characteristics 2 , but their needle-like fibre shape has
been compared to asbestos 3 , raising concerns that widespread use of carbon nanotubes …

Chronic obstructive pulmonary disease phenotypes: the future of COPD

…, JG Goldin, PW Jones, W MacNee… - American journal of …, 2010 - atsjournals.org
Significant heterogeneity of clinical presentation and disease progression exists within
chronic obstructive pulmonary disease (COPD). Although FEV 1 inadequately describes this …

Ultrafine (nanometre) particle mediated lung injury

K Donaldson, XY Li, W MacNee - Journal of aerosol science, 1998 - Elsevier
Experimental studies have shown that rats exposed to ultrafine particles of, for example,
titanium dioxide or carbon black, sustain more lung injury and pathology than rats exposed to …

Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines

DM Brown, MR Wilson, W MacNee, V Stone… - Toxicology and applied …, 2001 - Elsevier
Studies into the effects of ultrafine particles in the lung have shown adverse effects considered
to be due in part to the particle size. Air pollution particles (PM 10 ) are associated with …

[HTML][HTML] Characterisation of COPD heterogeneity in the ECLIPSE cohort

…, HO Coxson, LD Edwards, DA Lomas, W MacNee… - Respiratory …, 2010 - Springer
Background Chronic obstructive pulmonary disease (COPD) is a complex condition with
pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of …