Oxidative stress and regulation of glutathione in lung inflammation
I Rahman, W MacNee - European Respiratory Journal, 2000 - Eur Respiratory Soc
Inflammatory lung diseases are characterized by chronic inflammation and oxidant/antioxidant
imbalance, a major cause of cell damage. The development of an oxidant/antioxidant …
imbalance, a major cause of cell damage. The development of an oxidant/antioxidant …
Outcomes for COPD pharmacological trials: from lung function to biomarkers
M Cazzola, W MacNee, FJ Martinez… - European respiratory …, 2008 - Eur Respiratory Soc
The American Thoracic Society/European Respiratory Society jointly created a Task Force
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …
on “Outcomes for COPD pharmacological trials: from lung function to biomarkers” to inform …
Adverse cardiovascular effects of air pollution
…, PW Hadoke, NA Boon, W MacNee… - Nature clinical practice …, 2009 - nature.com
Air pollution is increasingly recognized as an important and modifiable determinant of
cardiovascular disease in urban communities. Acute exposure has been linked to a range of …
cardiovascular disease in urban communities. Acute exposure has been linked to a range of …
Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper
Background The Standards for the Diagnosis and Treatment of Patients with COPD
document 2004 updates the position papers on chronic obstructive pulmonary disease (COPD) …
document 2004 updates the position papers on chronic obstructive pulmonary disease (COPD) …
Particulate air pollution and acute health effects
A Seaton, D Godden, W MacNee, K Donaldson - The lancet, 1995 - Elsevier
Epidemiological studies have consistently shown an association between particulate air
pollution and not only exacerbations of illness in people with respiratory disease but also rises …
pollution and not only exacerbations of illness in people with respiratory disease but also rises …
Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study
Carbon nanotubes 1 have distinctive characteristics 2 , but their needle-like fibre shape has
been compared to asbestos 3 , raising concerns that widespread use of carbon nanotubes …
been compared to asbestos 3 , raising concerns that widespread use of carbon nanotubes …
Chronic obstructive pulmonary disease phenotypes: the future of COPD
…, JG Goldin, PW Jones, W MacNee… - American journal of …, 2010 - atsjournals.org
Significant heterogeneity of clinical presentation and disease progression exists within
chronic obstructive pulmonary disease (COPD). Although FEV 1 inadequately describes this …
chronic obstructive pulmonary disease (COPD). Although FEV 1 inadequately describes this …
Ultrafine (nanometre) particle mediated lung injury
K Donaldson, XY Li, W MacNee - Journal of aerosol science, 1998 - Elsevier
Experimental studies have shown that rats exposed to ultrafine particles of, for example,
titanium dioxide or carbon black, sustain more lung injury and pathology than rats exposed to …
titanium dioxide or carbon black, sustain more lung injury and pathology than rats exposed to …
Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines
Studies into the effects of ultrafine particles in the lung have shown adverse effects considered
to be due in part to the particle size. Air pollution particles (PM 10 ) are associated with …
to be due in part to the particle size. Air pollution particles (PM 10 ) are associated with …
[HTML][HTML] Characterisation of COPD heterogeneity in the ECLIPSE cohort
Background Chronic obstructive pulmonary disease (COPD) is a complex condition with
pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of …
pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of …