Brainstem gliomas are now regarded as a heterogeneous group of tumors that can be
distinguished by age of onset, clinical and radiological presentation and biological behavior …

Background There is no community standard for the treatment of glioblastoma in patients 70
years of age or older. We conducted a randomized trial that compared radiotherapy and …

Severe hypoxia [oxygen partial pressure (pO2) below 5–10 mmHg] is more frequent in
glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the …

In addition to multiple peripheral neurofibromas, Neurofibromatosis 1 (NF1) predisposes to
CNS tumours. Most of them are pilocytic astrocytomas, arise in children and are located in …

In contrast to childhood brainstem gliomas, adult brainstem gliomas are rare and poorly
understood. The charts of 48 adults suffering from brainstem glioma were reviewed in order …

The carcinogenic effect of radiofrequency electromagnetic fields in humans remains
controversial. However, it has been suggested that they could be involved in the aetiology of …

Purpose The management of glioblastoma multiforme (GBM) in elderly patients with poor
performance status is not well established. A trial evaluating the efficacy and safety of …

Angiogenesis inhibitors appear to be promising therapies for highly vascularized tumors
such as glioblastoma multiforme (GBM). Sunitinib is an oral multitargeted tyrosine kinase …

Background Gliomas are" intraparenchymally metastatic" tumors, invading the brain in a non-
destructive way that suggests cooperation between glioma cells and their environment …

Purpose Hypoxia in gliomas is associated with tumor resistance to radio-and chemotherapy.
However, positron emission tomography (PET) imaging of hypoxia remains challenging, and …