The process of drug discovery applies rigorous selection pressures. Marketed oral drugs will
generally possess favorable physiochemical properties with respect to absorption …

The apparent intrinsic clearance of 13 drugs has been determined using rat liver
microsomes at three different concentrations of microsomal protein. The kinetics was studied …

The aim of this study was to evaluate a unified method for predicting human in vivo intrinsic
clearance (CLint, in vivo) and hepatic clearance (CLh) from in vitro data in hepatocytes and …

The binding of 17 drugs to rat hepatocytes has been determined using equilibrium dialysis
in combination with metabolic inhibitors and a kinetic model for the binding and dialysis …

The distribution of four ionizing molecules between small unilamellar vesicles of
dimyristoylphosphatidylcholine (DMPC) and aqueous buffers has been studied as a function …

In this article approaches to predict human pharmacokinetics (PK) are discussed and the
capability of the exemplified methodologies to estimate individual PK parameters and …

Aims: To assess mortality in 1997 among 493 former workers of a US chromate production
plant employed for at least one year between 1940 and 1972. Methods: Cohort members …

Lipophilicity is an important parameter for any potential drug candidate. Accurate and
efficient lipophilicity measurements facilitate the development of high-quality predictive in …

Polypharmacy is a term that has been used in health care for decades. In conventional use,
it has meant the concurrent use of multiple medica-tions in the same patient. However, this …

OBJECTIVES To update and assess mortality from neoplasms to 31 December 1995 among
10 109 men employed in a job exposed to vinyl chloride for at least 1 year between 1942 …