Parkinson's disease (PD) is the second most common neurodegenerative disease, after
Alzheimer's disease. The potential causes of PD remain uncertain, but recent studies …

DNA-damaging agents are widely used in clinical oncology and exploit deficiencies in tumor
DNA repair. Given the expanding role of immune checkpoint blockade as a therapeutic …

Abstract The 2018 Nobel Prize in Physiology or Medicine was awarded to pioneers in the
field of cancer immunotherapy, as the utility of leveraging a patient's coordinated and …

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Loss-of-function mutations in parkin are the major cause of early-onset familial Parkinson's
disease. To investigate the pathogenic mechanism by which loss of parkin function causes …

The deposition of the abundant presynaptic brain protein α-synuclein as fibrillary aggregates
in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders …

Stratification of women according to their risk of breast cancer based on polygenic risk
scores (PRSs) could improve screening and prevention strategies. Our aim was to develop …

INTRODUCTION Most cancer patients die from cancer that recurs after spreading to a
different tissue, rather than from their original tumor. After successful treatment of the original …

Loss-of-function mutations in parkin are the predominant cause of familial Parkinson's
disease. We previously reported that parkin-/-mice exhibit nigrostriatal deficits in the …