An association between a quantitative measure of tactile acuity at the fingertips and symptoms of reduced manipulative function, as established by responses to a questionnaire, was demonstrated in a population of 81 manual workers from the mining industry (62 power-tool operators and 19 nonusers). Mechanoreceptor-specific vibrotactile thresholds were determined for the slowly adapting type I (SAI) and fast-adapting types I and II (FAI and FAII) receptors at the fingertip of the third digit of each hand. Statistically significant threshold shifts in SAI and/or FAII acuity were found in persons responding affirmatively to questions concerning finger/hand numbness, blanching, and difficulty buttoning clothing. The best predictors of a quantitative change in tactile acuity were questions relating to difficulty manipulating small objects and buttoning clothing, yielding positive predictive values of from 90% to 100% and false positive rates of from 0% to 2.8%. The demonstration of an association between a quantitative measure of tactile acuity at the fingertips and some symptom reports, obtained by means of a questionnaire, provides the basis for the development of a screening procedure for persons at risk of such disturbances in hand function.