Urinary 1-hydroxypyrene as a marker of exposure to pyrene: an epidemiological survey on a general population group

Sci Total Environ. 1997 Jul 1;199(3):247-54. doi: 10.1016/s0048-9697(97)05458-2.

Abstract

Urinary levels of 1-hydroxypyrene in a general adult population group are studied. Experimental data are not normally distributed; statistical analysis required a base 10 logarithmic transformation of data. The concentrations of urinary 1-hydroxypyrene measured were expressed as microgram g-1 urinary creatinine and are comparable with those reported by other authors, both for smoker and non-smoker subgroups. Multiple regression analysis shows that, for smokers, the number of cigarettes smoked per day and the body mass index (BMI) significantly influence the levels of urinary 1-hydroxypyrene expressed as microgram g-1 urinary creatinine, whereas no personal or behavioural variable (age, sex, alcohol consumption, dietary intake of pyrene, BMI) modified the 1-hydroxypyrene levels for non-smokers.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Alcohol Drinking
  • Biomarkers / urine
  • Body Mass Index
  • Cohort Studies
  • Creatinine / urine
  • Diet
  • Environmental Exposure*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutagens / analysis*
  • Mutagens / metabolism
  • Pyrenes / adverse effects*
  • Pyrenes / analysis*
  • Pyrenes / metabolism
  • Reference Values
  • Regression Analysis
  • Smoking
  • Urine / chemistry*

Substances

  • Biomarkers
  • Mutagens
  • Pyrenes
  • pyrene
  • Creatinine
  • 1-hydroxypyrene