Previous research has shown exposure-related increases in the prevalence of acquired color vision deficits among printers. We administered the Lanthony D-15 desaturated test of color vision to 82 print shop workers. Two tests of cognitive function, Trails A and B and the Symbol Digit Modalities Test, were also administered. Personal air sampling indicated that current exposure to organic solvents was highest among printers and lowest among bindery workers. In contrast to previous studies, the age-adjusted quantitative Lanthony D-15 desaturated test error scores did not differ significantly between exposure groups, and the proportion of subjects with > or = 1 error was greater in the lower-exposure, rather than higher-exposure, groups (P = .03). Of note, the proportion of subjects with > or = 2 errors did not differ significantly between groups (P = .24). Cognitive tests showed no significant association with exposure. These results are discussed in the context of methodological issues related to lighting sources, reliability of test results, and establishment of criteria for identifying deficits.