Abstract
The early renal function parameters (RFP), i.e. urinary alanine aminopeptidase (AAP), beta-galactosidase (beta GAL), N-acetyl-beta-D-glucosaminidase (NAG), retinol-binding protein (RBP), albumin (ALB), total protein (TP) and the conventional RFP plasma creatinine were assessed in 8 patients before and during treatment with the nephrotoxic antitumor agent cis-platin. Plasma creatinine increased during treatment with cis-platin. In all patients, acute tubular damage was revealed by early RFP. Albumin and total protein excretion patterns suggested alterations in glomerular function. The cumulative change in RBP excretion was related to plasma creatinine concentrations following cis-platin administration. The present study demonstrates that urinary RBP is a valuable parameter for the early assessment of cis-platin-induced nephrotoxicity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylglucosaminidase / urine
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Adult
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Albuminuria / chemically induced
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Albuminuria / enzymology
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Albuminuria / urine
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Aminopeptidases / urine
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CD13 Antigens
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Cisplatin / adverse effects*
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Cisplatin / therapeutic use
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Creatinine / blood
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Female
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Humans
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Kidney / drug effects*
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Kidney / physiopathology
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Kidney Diseases / chemically induced*
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Kidney Diseases / enzymology
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Kidney Diseases / urine*
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Middle Aged
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Ovarian Neoplasms / drug therapy
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Ovarian Neoplasms / physiopathology
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Proteinuria / chemically induced
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Proteinuria / enzymology
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Proteinuria / urine
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Retinol-Binding Proteins / urine
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Retinol-Binding Proteins, Plasma
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Time Factors
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Urinary Bladder Neoplasms / drug therapy
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Urinary Bladder Neoplasms / physiopathology
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Uterine Cervical Neoplasms / drug therapy
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Uterine Cervical Neoplasms / physiopathology
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beta-Galactosidase / urine
Substances
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Retinol-Binding Proteins
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Retinol-Binding Proteins, Plasma
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Creatinine
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beta-Galactosidase
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Acetylglucosaminidase
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Aminopeptidases
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CD13 Antigens
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Cisplatin