Relationships between visual display terminal (VDT) use and musculoskeletal problems were examined in a group of 353 office workers, using data from medical and workplace investigations as well as questionnaires. There were no general differences between VDT and non-VDT users as to the occurrence of muscle problems. Combinations of specific VDT work situations such as data entry work or work with a VDT for more than 20 h/week and the presence of some other factors were, however, associated with excess risks of certain muscle problems. The extraneous factors involved in the definitions of such risk groups were: use of bifocal or progressive glasses at a VDT; stomach-related stress reactions; limited rest break opportunity; repetitive movements; non-use of lower arm support; and possibly the vertical position of the keyboard; and presence of specular glare.