The relevance of hyperresponsiveness but not of atopy to FEV1 decline. Preliminary results in a working population

Bull Eur Physiopathol Respir. 1987 Jul-Aug;23(4):397-400.

Abstract

Five-year FEV1 decline in 329 working men was shown to be significantly related only among eversmokers to methacholine bronchial hyperresponsiveness (assessed at the end of follow-up), allergic rhinitis and rhinitis induced by cold air, independent of asthma and FEV1 level. Positive skin prick test was not associated with FEV1 decline.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Airway Obstruction / diagnosis
  • Airway Obstruction / epidemiology
  • Airway Obstruction / etiology
  • Asthma / diagnosis
  • Asthma / epidemiology*
  • Bronchial Provocation Tests
  • Cold Temperature
  • Humans
  • Longitudinal Studies
  • Male
  • Maximal Expiratory Flow Rate
  • Methacholine Chloride
  • Methacholine Compounds*
  • Middle Aged
  • Rhinitis, Allergic, Perennial / diagnosis
  • Rhinitis, Allergic, Perennial / epidemiology*
  • Rhinitis, Allergic, Perennial / etiology
  • Skin Tests
  • Smoking
  • United Kingdom

Substances

  • Methacholine Compounds
  • Methacholine Chloride