Abstract
Pneumoproteins, biomarkers of systemic inflammation and endothelial activation were studied across a season in 72 asphalt pavers, 32 asphalt plant operators and 19 asphalt engineers. Smokers had lower concentrations of Clara cell protein (CC-16) and surfactant protein A, but higher concentrations of surfactant protein D, interleukin 6, C-reactive protein, fibrinogen and intercellular adhesion molecule (ICAM)-1 than non-smokers. Smokers reporting wheezing had lower mean CC-16 concentration than smokers not reporting wheezing (5.7 vs 8.6 microg l(-1); p = 0.05). Cholesterol, P-selectin and ICAM-1 were lower in pavers and operators at the end compared with the start of the season. This may be related to increased physical activity during the season.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Biomarkers / analysis
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Cell Adhesion Molecules / analysis
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Construction Materials*
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Cytokines / blood
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Endothelium, Vascular / physiology
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Enzyme-Linked Immunosorbent Assay
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Female
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Fibrinogen
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Humans
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Hydrocarbons*
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Inflammation / metabolism*
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Interleukin-6
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Linear Models
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Lung / chemistry*
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Male
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Middle Aged
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Norway / epidemiology
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Obesity / complications
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Obesity / epidemiology
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Occupational Exposure / analysis*
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P-Selectin
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Proteins / chemistry*
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Respiratory Function Tests
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Respiratory Tract Diseases / epidemiology
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Seasons
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Smoking / epidemiology
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Spirometry
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Surveys and Questionnaires
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Young Adult
Substances
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Biomarkers
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Cell Adhesion Molecules
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Cytokines
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Hydrocarbons
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Interleukin-6
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P-Selectin
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Proteins
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asphalt
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Fibrinogen