Abstract
Correlations between in vitro hemolytic activity and the in vivo fibrogenic activity of a number of particulate materials are demonstrated. Fibrogenic particles are capable of inducing hemolysis, while non-fibrogenic particles are not. It is suggested that particulates inducing a rate of hemolysis greater than 1 X 10(-4) min-1 may be fibrogenic.
MeSH terms
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Animals
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Asbestos / toxicity
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Biphenyl Compounds / toxicity
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Calcium / toxicity
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Ceramics
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Erythrocytes / drug effects
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Hemolysis / drug effects*
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Hydrocarbons, Brominated / toxicity
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Kaolin / toxicity
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Magnesium / toxicity
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Particle Size
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Phosphates / toxicity
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Pulmonary Fibrosis / chemically induced*
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Rats
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Silicic Acid / toxicity
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Silicon Dioxide / toxicity
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Talc / toxicity
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Titanium / toxicity
Substances
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Biphenyl Compounds
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Hydrocarbons, Brominated
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Phosphates
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Asbestos
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Silicic Acid
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Talc
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Kaolin
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Silicon Dioxide
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Titanium
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Magnesium
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Calcium