In the area of occupational pain disability, a major barrier to effective rehabilitation of patients may be the extensive personal losses that can arise as secondary features of chronic pain disability. In this review, we discuss the concept of secondary loss and how it can have a profound impact on patients with occupational pain disability. Such secondary loss issues are extremely important to consider in any rehabilitation program in order to ensure the most comprehensive and compassionate treatment of these patients. We discuss the types of intervention that may be employed within the context of interdisciplinary rehabilitation programs.