Pathologic findings of silent hyperintense white matter lesions on MRI

J Neurol Sci. 1999 Aug 15;167(2):127-31. doi: 10.1016/s0022-510x(99)00158-6.

Abstract

The pathologic features of silent hyperintense white matter lesions in T2-weighted images on MRI were studied in patients with no neurologic signs or symptoms. The small patchy hyperintense white matter lesions represented myelin pallor associated with vessels showing hypertension and arteriosclerotic changes. 'Caps' also showed myelin pallor with dilated perivascular spaces. There were no lacunar infarcts in these lesions. Some of 'caps' was shown to be elongated normal lateral ventricle. 'Rims' of early stage revealed subependymal gliosis that was a part of normal aging processes.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Brain Injury, Chronic / diagnosis*
  • Humans
  • Magnetic Resonance Imaging*
  • Middle Aged