According to recent literature reviews, women seem to be especially prone to report symptoms of the so-called Sick-Building-Syndrome. In a large German study into the Sick-Building-Syndrome (the ProKlimA-project) 4596 persons from 14 buildings around Germany filled out a questionnaire regarding Sick-Building-symptoms and potential psychosocial determinants. The present article presents questionnaire results from 2517 female employees (as compared to 2079 male employees) which showed that women report higher scores in sensory irritation, a higher bodily complaint rate and more negative evaluation of the indoor climate. In addition most psychosocial variables showed less favourable scores for women as compared to men. Gender stratified logistic regression analysis suggests an effect of less favourable working conditions under which women are employed. Thus although women are more prone to express impairments in wellbeing, such expression has to be critically evaluated against the background of their living and working conditions.