Chest
Original ResearchDisorders of the PleuraHigh Risk of Malignant Mesothelioma and Pleural Plaques in Subjects Born Close to Ophiolites
Section snippets
Materials and Methods
Patients given a diagnosis of MM (International Classification of Diseases [ICD] code C45), breast cancer (ICD code C50), or prostate cancer (ICD code 61) between 2000 and 2010 were identified through the cancer registry of the Provincial Directorate of Health, to which physicians are mandated to declare malignant diseases. Patients given diagnoses of PPs (ICD code J92) made over the same period were identified from the digital databases of the two hospitals with a pulmonology division in Sivas
Results
Two-hundred sixty-one patients with either MM (n = 123) or PPs (n = 138), 178 patients with breast cancer, and 196 patients with prostate cancer were identified. Three patients with MM were excluded because they had been born in Tuzköy, a village in another province about 250 km away from Sivas and known for the presence of erionite.19 Birthplaces could be determined for 100 patients with MM (81%), 133 patients with PPs (96%), 161 patients with prostate cancer (82%), and 139 patients with
Discussion
We demonstrated that two conditions that have been well established to result from exposure to asbestos, namely MM and PPs, were closely related to the proximity of the subject's birthplace to sources of NOA (ophiolites). Having been born close to ophiolites was associated with a substantially increased risk of MM or PPs, compared with two other types of cancer, with women appearing to be at higher risk than men.
The occurrence of MM or PPs in relation to ophiolites in the northwest area of the
Conclusions
Although the industrial use of asbestos has been banned or restricted in many countries, benign and malignant diseases due to asbestos will not disappear for many years, as a result of the presence of asbestos in many buildings and products.33 Even though the incidence of “endemic” MM resulting from the use of NOA fibers for whitewashing houses has been shown to have decreased in some areas,34 our study and our observations in the field suggest that the epidemic will remain present for many
Acknowledgments
Author contributions: Dr Bayram is the guarantor and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Dr Bayram: contributed to the concept and design of the study; acquisition, analysis, and interpretation of data; drafting of the article; and critical revision of the article for important intellectual content.
Dr Dongel: contributed to the acquisition, analysis, and interpretation of data and writing of the article.
Dr Bakan: contributed to the concept
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2020, Ecotoxicology and Environmental SafetyCitation Excerpt :Naturally occurring asbestiform fibers refer to the natural mineral of soils, sediments or rocks and their release as fibers into the air by human activities or natural weathering processes represents a risk for human exposure (Bayram et al., 2013).
Epidemiology of Environmental Exposure and Malignant Mesothelioma
2017, Journal of Thoracic OncologyCitation Excerpt :These studies were mostly descriptive with a cross-sectional study design. There were five cohort studies that investigated cases of MM survival.30,33,34,59,60 Nine studies used a case-control design,29,33–36,44,51,60,64 two of which were nested case-control studies.44,60
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2017, Annals of EpidemiologyNatural carcinogenic fiber and pleural plaques assessment in a general population: A cross-sectional study
2016, Environmental ResearchCitation Excerpt :Several studies reported a high incidence of MM due to NOA in: rural regions of Turkey (Metintas et al., 2005; Senyigit et al., 2004; Dumortier et al., 1998; Yazicioglu et al., 1980; Döngel et al., 2013), Central Anatolia, caused by exposure to erionite fibers; in Mediterranean countries, including Corsica (Rey et al., 1993), Cyprus (McConnochie et al., 1987) and Greece (Constantopoulos, 2008), Finland (Koskinen et al., 1996) and in other sites of the world, including California (Pan et al., 2005); China (Luo et al., 2003) and New Caledonia (Baumann et al., 2011). Also in our study, as in all previous NOA exposure ones (Bayram et al., 2013; Metintas et al., 2005; Yazicioglu et al., 1980; Rey et al., 1993; Koskinen et al., 1996; Luo et al., 2003; Baris et al., 1988), we have observed the presence of PPs in exposed population. In this survey, PPs were found in 16% (n=218/1240) of the screened population and more than 60% of patients affected with plaques were males.
Environmental asbestos exposure and nonmalignant pleural findings: a retrospective evaluation of a five-year chest CT repository
2022, Archives of Environmental and Occupational Health
Funding/Support: The authors have reported to CHEST that no funding was received for this study.
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