Chest
Total Circulating IgE and FEV1 in Adult Men: An Epidemiologic Longitudinal Study
Section snippets
Study Population
In 1980 to 1981 and 1985 to 1986, a longitudinal survey was conducted in a working population from the Parisian police. The initial population, in 1980, consisted of 912 men aged 22 to 55 years who were interviewed with a standardized questionnaire; spirometric tracings were performed and 817 men satisfied the European Coal and Steel Community (ECSC) quality tracing criteria. A second survey was performed five years later on a subsample of the original sample with good spirometric tracings. The
RESULTS
Seven percent of men reported asthma at one of the two surveys. A similar percentage of subjects reported usual phlegm production in 1985 to 1986. At the second survey, 15 percent of men were SPT positive and only 4 percent were directly exposed to vehicular traffic. Men were surveyed more during autumn (55 percent) than during summer (25 percent) and winter (20 percent) and were not surveyed at all during spring. Thirty-five percent were nonsmokers, 28 percent had stopped smoking for at least
DISCUSSION
Observations from this longitudinal study conducted in adult men among whom total circulating IgE levels were measured at the end of a five-year follow-up showed the following: (1) IgE level was inversely related to lung function performed at the time of IgE determination, especially in nonsmokers; and (2) increased IgE level was associated with a steeper FEV1 decline during the interval of follow-up in nonsmokers and exsmokers. The relation was observed among exsmokers independently of
ACKNOWLEDGMENTS
The authors wish to thank N. Barrault, C. Henry, M. Korobaeff, M. N. Maquaire, J. Sahuquillo, and L. Villoingt for help in collecting data and the men who participated in the study.
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Supported in part by Grants No. 87-G/2 and No. 88-G/7 from Fonds Spécial des Comités Départementaux contre les Maladies Respiratoires et la Tuberculose, Paris, France.