Abstract
Objective: To investigate potential associations between diet and adult glioma. Methods: We conducted a population-based case–control study of adult glioma in eastern Nebraska. Nutrient and food group intakes were estimated for 236 glioma cases and 449 controls using information obtained from a food-frequency questionnaire. Results: After adjusting for potential confounders, inverse associations with risk of adult glioma were observed for intakes of dark yellow vegetables (highest quartile versus lowest: OR = 0.6, p trend = 0.03) and beans (OR = 0.4, p trend = 0.0003), but no associations were seen for dietary sources of preformed nitrosamines or high-nitrate vegetables. Our nutrient analysis revealed significant inverse associations between risk of adult glioma and dietary intake of pro-vitamin A carotenoids (highest quartile versus lowest: OR = 0.5, p trend = 0.005), α-carotene (OR = 0.5, p trend = 0.01), β-carotene (OR = 0.5, p trend = 0.01), dietary fiber (OR = 0.6, p trend = 0.048) and fiber from beans (OR = 0.5, p trend = 0.0002). We observed no significant associations with risk of adult glioma for intakes of other nutrients or compounds including nitrate, nitrite, vitamin C, vitamin E, saturated fat, cholesterol, dietary fiber from grain products, or fiber from fruit and vegetables. Conclusion: Our study does not support the N-nitroso compound hypothesis, but suggests potential roles for carotenoids and possibly other phytochemicals in reducing risk of adult glioma.
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Ries L, Eisner M, Kosary C, et al., eds (2000) SEER Cancer Statistics Review, 1973–1997. Bethesda, MD: National Cancer Institute.
Thomas T, Inskip P (1996) Brain and other nervous system. In: Harras A, Edwards B, Blot W, Ries LG, eds. Cancer Rates and Risks. Bethesda, MD: National Cancer Institute, NIH, pp. 114–119.
Inskip PD, Linet MS, Heineman EF (1995) Etiology of brain tumors in adults. Epidemiol Rev 17: 382–414.
Hathcock J, ed. (1982) Nutritional Toxicology, Vol. 1. New York: Academic Press, pp. 327–381.
Boeing H, Schlehofer B, Blettner M, Wahrendorf J (1993) Dietary carcinogens and the risk for glioma and meningioma in Germany. Int J Cancer 53: 561–565.
Giles GG, McNeil JJ, Donnan G, et al. (1994) Dietary factors and the risk of glioma in adults: results of a case-control study in Melbourne, Australia. Int J Cancer 59: 357–362.
Ahlbom A, Navier IL, Norell S, Olin R, Spannare B (1986) Nonoccupational risk indicators for astrocytomas in adults. Am J Epidemiol 124: 334–337.
Blowers L, Preston-Martin S, Mack WJ (1997) Dietary and other lifestyle factors of women with brain gliomas in Los Angeles County (California, USA). Cancer Causes Control 8: 5–12.
Lee M, Wrensch M, Miike R(1997) Dietary and tobacco risk factors for adult onset glioma in the San Francisco Bay Area (California, USA). Cancer Causes Control 8: 13–24.
Hu J, La Vecchia C, Negri E, et al. (1999) Diet and brain cancer in adults: a case-control study in northeast China. Int J Cancer 81: 20–23.
Burch JD, Craib KJ, Choi BC, et al. (1987) An exploratory case-control study of brain tumors in adults. J Natl Cancer Inst 78: 601–609.
Preston-Martin S, Mack W, Henderson BE (1989) Risk factors for gliomas and meningiomas in males in Los Angeles County. Cancer Res 49: 6137–6143.
Mills PK, Preston-Martin S, Annegers JF, et al. (1989) Risk factors for tumors of the brain and cranial meninges in Seventh-Day Adventists. Neuroepidemiology 8: 266–275.
Hochberg F, Toniolo P, Cole P, Salcman M (1990) Nonoccupational risk indicators of glioblastoma in adults. J Neurooncol 8: 55–60.
Ryan P, Lee MW, North B, McMichael AJ (1992) Risk factors for tumors of the brain and meninges: results from the Adelaide Adult Brain Tumor Study. Int J Cancer 51: 20–27.
Kaplan S, Novikov I, Modan B (1997) Nutritional factors in the etiology of brain tumors: potential role of nitrosamines, fat, and cholesterol. Am J Epidemiol 146: 832–841.
Hu J, Johnson KC, Mao Y, et al. (1998) Risk factors for glioma in adults: a case-control study in northeast China. Cancer Detect Prev 22: 100–108.
Schwartzbaum JA, Fisher JL, Goodman J, Octaviano D, Cornwell DG (1999) Hypotheses concerning roles of dietary energy, cured meat, and serum tocopherols in adult glioma development. Neuroepidemiology 18: 156–166.
Davey-Smith G, Shipley M (1989) Plasma cholesterol concentration and primary brain tumors. BMJ 299: 26–27.
Neugut AI, Fink DJ, Radin D (1989) Serum cholesterol and primary brain tumours: a case-control study. Int J Epidemiol 18: 798–801.
Nygren C, von Holst H, Mansson JE, Fredman P (1997) Increased levels of cholesterol esters in glioma tissue and surrounding areas of human brain. Br J Neurosurg 11: 216–220.
Davey-Smith G, Neaton JD, Ben-Shlomo Y, Shipley M, Wentworth D (1992) Serum cholesterol concentration and primary malignant brain tumors: a prospective study. Am J Epidemiol 135: 259–265.
Knekt P, Reunanen A, Teppo L (1991) Serum cholesterol concentration and risk of primary brain tumours. BMJ 302: 90.
Herrinton LJ, Friedman GD (1995) Serum cholesterol concentration and risk of brain cancer. BMJ 310: 367–368.
Ward MH, Sinha R, Heineman EF, et al. (1997) Risk of adenocarcinoma of the stomach and esophagus with meat cooking method and doneness preference. Int J Cancer 71: 14–19.
Zahm SH, Weisenburger DD, Babbitt PA, et al. (1990) A case-control study of non-Hodgkin's lymphoma and the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) in eastern Nebraska. Epidemiology 1: 349–356. 654 H. Chen et al.
Ward M, Zahm S, Weisenburger D, et al. (1994) Dietary factors and non-Hodgkin's lymphoma in Nebraska (United States). Cancer Causes Control 5: 422–432.
Block G, Hartman AM, Naughton D (1990) A reduced dietary questionnaire: development and validation. Epidemiology 1: 58–64.
Panalaks T, Iyengar J, Donaldson B, Miles W, Sen N (1974) Further survey of cured meat products for volatile N-nitrosamine. J Assoc Official Anal Chem 57: 806–812.
Chilvers C, Inskip H, Caygill C, et al. (1984) A survey of dietary nitrate in well-water users. Int J Epidemiol 13: 324–331.
Panalaks T, Iyengar JR, Sen NP (1973) Nitrate, nitrite, and dimethylnitrosamine in cured meat products. J Assoc Official Anal Chem 56: 621–625.
Howe GR, Harrison L, Jain M (1986) A short diet history for assessing dietary exposure to N-nitrosamines in epidemiologic studies. Am J Epidemiol 124: 595–602.
White JW, Jr (1975) Relative significance of dietary sources of nitrate and nitrite. J Agric Food Chem 23: 886–891.
National Academy of Sciences (1981) The Health Effects of Nitrate, Nitrite and N-nitroso Compounds. Washington, DC: National Academy Press.
Sinha R, Rothman N, Salmon CP, et al. (1998) Heterocyclic amine content in beef cooked by different methods to varying degrees of doneness and gravy made from meat drippings. Food Chem Toxicol 36: 279–287.
Willett WC, Howe GR, Kushi LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65: 1220S-1228S; discussion 1229S-1231S.
Preston-Martin S, Mack W (1991) Gliomas and meningiomas in men in Los Angeles County: investigation of exposures to Nnitroso compounds. IARC Sci Publ 105: 197–203.
Messina MJ (1999) Legumes and soybeans: overview of their nutritional profiles and health effects. Am J Clin Nutr 70: 439S-450S.
Slavin JL, Martini MC, Jacobs DR, Jr, Marquart L (1999) Plausible mechanisms for the protectiveness of whole grains. Am J Clin Nutr 70: 459S-463S.
Chen H, Ward M, Graubard B, et al. (2002) Nutrient intakes and adenocarcinoma of the esophagus and distal stomach. Nutr Cancer (In press).
Friedenreich CM, Slimani N, Riboli E (1992) Measurement of past diet: review of previous and proposed methods. Epidemiol Rev 14: 177–196.
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Chen, H., Ward, M.H., Tucker, K.L. et al. Diet and risk of adult glioma in eastern Nebraska, United States. Cancer Causes Control 13, 647–655 (2002). https://doi.org/10.1023/A:1019527225197
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DOI: https://doi.org/10.1023/A:1019527225197