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Sinonasal cancer and occupational exposures: a pooled analysis of 12 case–control studies

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Objective: In order to examine the associations between sinonasal cancer and occupational exposures other than wood dust and leather dust, the data from 12 case–control studies conducted in seven countries were pooled and reanalyzed. Methods: The pooled data set included 195 adenocarcinoma cases (169 men and 26 women), 432 squamous cell carcinomas (330 men and 102 women), and 3136 controls (2349 men and 787 women). Occupational exposures to formaldehyde, silica dust, textile dust, coal dust, flour dust, asbestos, and man-made vitreous fibers were assessed with a job-exposure matrix. Odds ratios (ORs) were adjusted for age, study, wood dust, and leather dust, or other occupational exposures when relevant. 95% confidence intervals (CIs) were estimated by unconditional logistic regression. Results: A significantly increased risk of adenocarcinoma was associated with exposure to formaldehyde. The ORs for the highest level of exposure were 3.0 (CI = 1.5–5.7) among men and 6.2 (CI = 2.0–19.7) among women. An elevated risk of squamous cell carcinoma was observed among men (OR = 2.5, CI = 0.6–10.1) and women (OR = 3.5, CI = 1.2–10.5) with a high probability of exposure to formaldehyde. Exposure to textile dust was associated with non-significantly elevated risk of adenocarcinoma, among women only: the OR for the high level of cumulative exposure was 2.5 (CI = 0.7–9.0). High level of asbestos exposure was associated with a significantly increased risk of squamous cell carcinoma among men (OR = 1.6, CI = 1.1–2.3). Conclusions: The results of this pooled analysis support the hypothesis that occupational exposure to formaldehyde increases the risk of sinonasal cancer, particularly of adenocarcinoma. They also indicate an elevated risk of adenocarcinoma among women exposed to textile dust, and suggest that exposure to asbestos may increase the risk of squamous cell carcinoma.

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References

  1. International Agency for Research on Cancer (1995) Wood Dust and Formaldehyde. IARC Monogr Eval Carcinog Risks Hum, Vol 62. Lyon: IARC.

  2. Pippard EC, Acheson ED (1985) The mortality of boot and shoe makers, with special reference tocancer. Scand J Work Environ Health 11: 249–255.

    Google Scholar 

  3. Olsen JH (1988) Occupational risks of sinonasal cancer in Denmark. Br J Ind Med 45: 329–335.

    Google Scholar 

  4. International Agency for Research on Cancer (1987) Leather industries: boot and shoe manufacture and repair. In: Overall evaluations of carcinogenicity: an updating of IARC Monographs volumes 1 to 42. IARC Monogr Eval Carcinog Risks Hum, Suppl. 7. Lyon: IARC, pp. 232–235.

  5. Andersen A, Barlow L, Engeland A, Kjaerheim K, Lynge E, Pukkala E (1999) Work-related cancer in the Nordic countries. Scand J Work Environ Health 25 (Suppl. 2): 1–116.

    Google Scholar 

  6. Cecchi F, Buiatti E, Kriebel D, Nastasi L, Santucci M (1980) Adenocarcinoma of the nose and paranasal sinuses in shoemakers and woodworkers in the province of Florence, Italy (1963–77). Br J Ind Med 37: 222–225.

    Google Scholar 

  7. Comba P, Barbieri PG, Battista G, et al. (1992) Cancer of the nose and paranasal sinuses in the metal industry: a case-control study. Br J Ind Med 49: 193–196.

    Google Scholar 

  8. Comba P, Battista G, Belli S, et al. (1992) A case-control study of cancer of the nose and paranasal sinuses and occupational exposures. Am J Ind Med 22: 511–520.

    Google Scholar 

  9. Merler E, Baldasseroni A, Laria R, et al. (1986) On the causal association between exposure to leather dust and nasal cancer: further evidence from a case-control study. Br J Ind Med 43: 91–95.

    Google Scholar 

  10. Brinton LA, Blot WJ, Fraumeni JFJ (1985) Nasal cancer in the textile and clothing industries. Br J Ind Med 42: 469–474.

    Google Scholar 

  11. Acheson ED, Cowdell RH, Rang EH (1981) Nasal cancer in England and Wales: an occupational survey. Br J Ind Med 38: 218–224.

    Google Scholar 

  12. Malker HS, McLaughlin JK, Blott WJ, et al. (1986) Nasal cancer and occupation in Sweden, 1961–1979. Am J Ind Med 9: 477–485.

    Google Scholar 

  13. Ng TP (1986) A case-referent study of cancer of the nasal cavity and sinuses in Hong Kong. Int J Epidemiol 15: 171–175.

    Google Scholar 

  14. Luce D, Gerin M, Morcet JF, Leclerc A (1997) Sinonasal cancer and occupational exposure to textile dust. Am J Ind Med 32: 205–210.

    Google Scholar 

  15. Leclerc A, Luce D, Demers PA, et al. (1997) Sinonasal cancer and occupation. Results from the reanalysis of twelve case-control studies. Am J Ind Med 31: 153–165.

    Google Scholar 

  16. Luce D, Leclerc A, Morcet JF, et al. (1992) Occupational risk factors for sinonasal cancer: a case-control study in France. Am J Ind Med 21: 163–175.

    Google Scholar 

  17. International Agency for Research on Cancer (1990) Chromium, Nickel and Welding. IARC Monogr Eval Carcinog Risks Hum, Vol. 49. Lyon: IARC.

  18. Hayes RB, Raatgever JW, de Bruyn A, Gerin M (1986) Cancer of the nasal cavity and paranasal sinuses, and formaldehyde exposure. Int J Cancer 37: 487–492.

    Google Scholar 

  19. Olsen JH, Asnaes S (1986) Formaldehyde and the risk of squamous cell carcinoma of the sinonasal cavities. Br J Ind Med 43: 769–774.

    Google Scholar 

  20. Parkin DM, Whelan SL, Ferlay L, Raymond L, Young J, eds. (1997) Cancer Incidence in Five Continents, Vol. VII. IARC Scientific Publications No. 143. Lyon: IARC.

  21. Roush GC (1996) Cancers of the nasal cavity and paranasal sinuses. In: Schottenfeld D, Fraumeni JFJ, eds. Cancer Epidemiology and Prevention. New York: Oxford University Press, pp. 587–602.

    Google Scholar 

  22. Demers PA, Kogevinas M, Boffetta P, et al. (1995) Wood dust and sino-nasal cancer: pooled reanalysis of twelve case-control studies. Am J Ind Med 28: 151–166.

    Google Scholar 

  23. 't Mannetje A, Kogevinas M, Luce D, et al. (1999) Sinonasal cancer, occupation, and tobacco smoking in European women and men. Am J Ind Med 36: 101–107.

    Google Scholar 

  24. Demers PA, Boffetta P (1998) Cancer Risk from Occupational Exposure to Wood Dust: a pooled analysis of epidemiological studies. IARC Technical report No. 30. Lyon: IARC.

  25. Vaughan TL, Strader C, Davis S, Daling JR (1986) Formaldehyde and cancers of the pharynx, sinus and nasal cavity: I. Occupational exposures. Int J Cancer 38: 677–683.

    Google Scholar 

  26. Luce D, Gerin M, Leclerc A, Morcet JF, Brugere J, Goldberg M (1993) Sinonasal cancer and occupational exposure to formaldehyde and other substances. Int J Cancer 53: 224–231.

    Google Scholar 

  27. Roush GC, Walrath J, Stayner LT, Kaplan SA, Flannery JT, Blair A (1987) Nasopharyngeal cancer, sinonasal cancer, and occupations related to formaldehyde: a case-control study. J Natl Cancer Inst 79: 1221–1224.

    Google Scholar 

  28. Magnani C, Comba P, Ferraris F, Ivaldi C, Meneghin M, Terracini B (1993) A case-control study of carcinomas of the nose and paranasal sinuses in the woolen textile manufacturing industry. Arch Environ Health 48: 94–97.

    Google Scholar 

  29. Hayes RB, Gerin M, Raatgever JW, de Bruyn A (1986) Woodrelated occupations, wood dust exposure, and sinonasal cancer. Am J Epidemiol 124: 569–577.

    Google Scholar 

  30. Zheng W, Blot WJ, Shu XO, et al. (1992) A population-based case-control study of cancers of the nasal cavity and paranasal sinuses in Shanghai. Int J Cancer 52: 557–561.

    Google Scholar 

  31. Acheson ED, Cowdell RH, Rang E (1972) Adenocarcinoma of the nasal cavity and sinuses in England and Wales. Br J Ind Med 29: 21–30.

    Google Scholar 

  32. Hernberg S, Westerholm P, Schultz-Larsen K, et al. (1983) Nasal and sinonasal cancer. Connection with occupational exposures in Denmark, Finland and Sweden. Scand J Work Environ Health 9: 315–326.

    Google Scholar 

  33. International Agency for Research on Cancer (1987) Asbestos. In: Overall evaluations of carcinogenicity: an updating of IARC Monographs volumes 1 to 42. IARC Monogr Eval Carcinog Risks Hum, Suppl. 7. Lyon: IARC, pp. 106–116.

  34. Leclerc A, Martinez CM, Gerin M, Luce D, Brugere J (1994) Sinonasal cancer and wood dust exposure: results from a case-control study. Am J Epidemiol 140: 340–349.

    Google Scholar 

  35. Bolm-Audorff U, Vogel C, Woitowitz H (1990) Occupation and smoking as risk factors of nasal and nasopharyngeal cancer. In: Sakurai Hea, ed. Occupational Epidemiology. New York: Elsevier Science Publishers, pp. 71–74.

    Google Scholar 

  36. Hardell L, Johansson B, Axelson O (1982) Epidemiological study of nasal and nasopharyngeal cancer and their relation to phenoxy acid or chlorophenol exposure. Am J Ind Med 3: 247–257.

    Google Scholar 

  37. Vaughan TL (1989) Occupation and squamous cell cancers of the pharynx and sinonasal cavity. Am J Ind Med 16: 493–510.

    Google Scholar 

  38. Vaughan TL, Davis S (1991) Wood dust exposure and squamous cell cancers of the upper respiratory tract. Am J Epidemiol 133: 560–564.

    Google Scholar 

  39. Brinton LA, Blot WJ, Becker JA, et al. (1984) A case-control study of cancers of the nasal cavity and paranasal sinuses. Am J Epidemiol 119: 896–906.

    Google Scholar 

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Luce, D., Leclerc, A., Bégin, D. et al. Sinonasal cancer and occupational exposures: a pooled analysis of 12 case–control studies. Cancer Causes Control 13, 147–157 (2002). https://doi.org/10.1023/A:1014350004255

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