Abstract
Objective: To study the risk of kidney cancer following asbestos exposure.
Methods: We carried out a meta-analysis of the results of cohort studies of workers predominantly exposed to asbestos. We contacted the authors of 70 cohort studies; published results were available from the reports of 10 cohorts; we obtained the relevant information for an additional 27 cohorts.
Results: The studies included in the analysis comprised a total of 169 kidney cancer deaths and 69 incident cases. The overall pooled standardized mortality ratio (SMR) of kidney cancer was 1.1, with a 95% confidence interval (95% CI) of 0.9–1.3. The pooled SMR was higher for workers with undefined asbestos exposure (SMR 1.2, 95% CI 0.9–1.6) than for workers with either predominant chrysotile (SMR 0.9, 95% CI 0.7–1.3) or some amphibole (SMR 0.96, 95% CI 0.6–1.5) exposure. Studies with published results had higher SMRs than studies for which information was obtained from the authors. Studies with high asbestos exposure and an elevated SMR of lung cancer tended to show an increased risk of kidney cancer.
Conclusions: It is unlikely that asbestos exposure is responsible for an important increase in kidney cancer risk; however, high asbestos exposure might entail a small increase in risk.
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References
Mandel JS, McLaughlin JK, Schlehofer B, et al. (1995) International renal-cell cancer study, IV, Occupation. Int J Cancer 61: 601–605.
Smith AH, Shearn VI, Wood R (1989) Asbestos and kidney cancer: the evidence supports a causal association. Am J Ind Med 16: 159–166.
Enterline PE, Henderson V (1990) Re: Asbestos and kidney cancer. Am J Ind Med 17: 645–646 (letter).
Edelman DA (1992) Does asbestos exposure increase the risk of urogenital cancer? Int Arch Occup Environ Health 63: 469–475.
Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. Br Med J 315: 629–634.
Greenland S (1998) Meta-analysis. In: Rothman KJ, Greenland S, eds. Modern Epidemiology, 2nd edn. Philadelphia, PA: Lippincott-Raven, pp. 643–673.
Der Simonian R, Laird N (1986) Meta-analysis in clinical trials. Controlled Clin Trials 7: 177–188.
Stata Corporation (1997) Stata Statistical Software, Release 5.0. College Station, TX: Stata Corporation.
Neuberger M, Kundi M (1990) Individual asbestos exposure: smoking and mortality - a cohort study in the asbestos cement industry. Br J Ind Med 47: 615–620.
McDonald JC, Liddell FDK, Dufresne A, McDonald AD (1993) The 1891–1920 birth cohort of Quebec chrysotile miners and millers: mortality 1976–88. Br J Ind Med 50: 1073–1081.
Tulchinsky TH, Ginsberg GM, Shihab S, Goldberg E, Laster R (1992) Mesothelioma mortality among former asbestos-cement workers in Israel, 1953–90. Isr J Med Sci 28: 543–547.
Szeszenia-Dabrowska N, Wilczynska U, Szymczak W (1988) Mortality among female workers in an asbestos factory in Poland. Pol J Occup Med 1: 203–212.
Wilczynska U, Szeszenia-Dabrowska N, Szymczak W (1996) Mortality from malignant neoplasms in men occupationally exposed to asbestos dust. Med Pr 47: 437–443 (in Polish).
Albin M, Jakobsson K, Attewell R, Johansson L, Welinder H (1990) Mortality and cancer morbidity in cohorts of asbestos cement workers and referents. Br J Ind Med 47: 602–610.
Ohlson C-G, Hogstedt C (1985) Lung cancer among asbestos cement workers: a Swedish cohort study and a review. Br J Ind Med 42: 397–402.
Peto J, Doll R, Hermon C, Binns W, Clayton R, Goffe T (1985) Relationship of mortality to measures of environmental asbestos pollution in an asbestos textile factory. Ann Occup Hyg 29: 305–355.
Acheson ED, Gardner MF, Pippard EC, Grime LP (1982) Mortality of two groups of women who manufactured gas masks from chrysotile and crocidolite asbestos: a 40–year follow-up. Br J Ind Med 39: 344–348.
Gardner MJ, Winter PD, Pannett B, Powell CA (1986) Follow up study of workers manufacturing chrysotile asbestos cement products. Br J Ind Med 43: 726–732.
Thomas HF, Benjamin IT, Elwood PC, Sweetnam PM (1982) Further follow-up study of workers from an asbestos cement factory. Br J Ind Med 39: 273–276.
Hughes JM, Weill H, Hammad YY (1987) Mortality of workers employed in two asbestos cement manufacturing plants. Br J Ind Med 44: 161–174.
Dement JM, Brown DP, Okun A (1994) Follow-up study of chrysotile asbestos textile workers: cohort mortality and case-control analyses. Am J Ind Med 26: 431–447.
Armstrong BK, de Klerk NH, Musk AW, Hobbs MST (1988) Mortality in miners and millers of crocidolite in Western Australia. Br J Ind Med 45: 5–13.
Raffin E, Villadsen E, Engholm G, Lynge E (1996) Lung cancer in asbestos cement workers in Denmark. Occup Environ Med 53: 399–402.
Meurman LO, Pukkala E, Hakama M (1994) Incidence of cancer among anthophyllite asbestos miners in Finland. Occup Environ Med 51: 421–425.
Magnani C, Terracini B, Ivaldi C, Mancini A, Botta M (1996) Mortality for cancer and other causes in asbestos cement workers at Casale Monferrato. Med Lav 87: 133–146 (in Italian).
Pettinari A, Mengucci R, Belli S, Comba P (1994) Mortality of workers employed at an asbestos cement manufacturing plant in Senigallia. Med Lav 85: 223–230 (in Italian).
Sandén A, Jaörvholm B, Larsson S, Thiringer G (1992) The risk of lung cancer and mesothelioma after cessation of asbestos exposure: a prospective cohort study of shipyard workers. Eur Respir J 5: 281–285.
Acheson ED, Gardner MU, Winder PD, Bennett C (1984) Cancer in a factory using amosite asbestos. Int J Epidemiol 13: 3–10.
Ribak J, Seidman H, Seliko IJ (1989) Amosite mesothelioma in a cohort of asbestos workers. Scand J Work Environ Health 15: 106–110.
Roösler JA, Woitowitz HJ (1995) Recent data on cancer due to asbestos in Germany. Med Lav 86: 440–448.
Germani D, Grignoli M, Belli S, et al. (1996) A mortality study of recipients of compensation for asbestosis in Italy (1980–1990). Med Lav 87: 371–385 (in Italian).
Puntoni R, Merlo F, Ceppi M, Reggiardo G, Borsa L (1998) A 5istorical cohort mortality study among shipyard workers in Genoa, Italy (1960–1995). Proc Am Assoc Cancer Res 39: 100 (abstract).
Szeszenia-Dabrowska N, Wilczynska U, Szymczak W (1997) Cancer risk in asbestos-cement industry workers in Poland. Med Pr 48: 473–483 (in Polish).
Englund A (1995) Recent data on cancer due to asbestos in Sweden. Med Lav 86: 435–439.
Ohlson C-G, Klaesson B, Hogstedt C (1984) Mortality among asbestos-exposed workers in a railroad workshop. Scand J Work Environ Health 10: 283–291.
Hodgson JT, Jones RD (1986) Mortality of asbestos workers in England and Wales 1971–81. Br J Ind Med 43: 158–164.
Newhouse ML, Berry G, Wagner JC (1985) Mortality of factory workers in east London 1933–80. Br J Ind Med 42: 4–11.
Enterline PE, Hartley J, Henderson V (1987) Asbestos and cancer: a cohort followed up to death. Br J Ind Med 44: 396–401.
Seliko. IJ, Cuyler Hammond E, Seidman H (1979a) Mortality experience of insulation workers in the United States and Canada, 1943–76. Ann NY Acad Sci 330: 91–116.
Seliko. IJ, Lilis R, Nicholson WJ (1979b) Asbestos disease in United States shipyards. Ann NY Acad Sci 330: 295–311.
Seliko. IJ, Seidman H (1991) Asbestos-associated deaths among insulation workers in the United States and Canada, 1967–1987. Ann NY Acad Sci 643: 1–14.
Kolonel LN, Yoshizawa CN, Hirohata T, Myers BC (1985) Cancer occurrence in shipyard workers exposed to asbestos in Hawaii. Cancer Res 45: 3924–3928.
Chen LJ, Li QL, Hu TX, Guo JS (1988) A historical prospective investigation of malignant tumour in Shanghai asbestos product factory. Labour Med (Laodong Yixue) 1: 6–9 (in Chinese).
Zou S, Wu Y, Ma F, Ma H, Sueng W, Jiang Z (1990) Retrospective mortality study of asbestos workers in Laiyuan. In: Proceedings of the VII International Pneumoconiosis Conference, Pittsburgh, PA, USA, 23–26 August 1988 (NIOSH Publ. No.), Part II, pp. 1242–1244.
Cheng W-N, Kong J (1992) A retrospective mortality cohort study of chrysotile asbestos products workers in Tianjin 1972–1987. Environ Res 59: 271–278.
Piolatto G, Negri E, La Vacchia C, Pira E, Decarli A, Peto J (1990) An update of cancer mortality among chrysotile asbestos miners in Balangero, northern Italy. Br J Ind Med 47: 810–814.
Weiss W (1977) Mortality of a cohort exposed to chrysotile asbestos. J Occup Med 191: 737–740.
McDonald AD, Fry JS, Woolley AJ, McDonald JC (1984) Dust exposure and mortality in an American chrysotile asbestos friction products plant. Br J Ind Med 41: 151–157.
Gurvich EB, Gladkova EV, Gutnikova OV, Kostiukovskaia AV, Kuzina LE, Saprykova VV (1993) Epidemiology of chronic, precancerous and oncologic diseases in workers of asbestos and cement industry. Med Tr Prom Ekol 5–6: 4–6 (in Russian).
Kogan PM, Yatsenko AS, Tregubov ES, Gurvich EB, Kuzina LE (1993) Evaluation of carcinogenic risk in friction product workers. Med Lav 84: 290–296.
Finkelstein MM (1984) Mortality among employees of an Ontario asbestos-cement factory. Am Rev Respir Dis 129: 754–761.
Finkelstein MM (1989) Mortality among employees of an Ontario factory manufacturing insulation materials from amosite asbestos. Am J Ind Med 15: 477–481.
Alies-Patin AM, Valleron AJ (1985) Mortality of workers in a French asbestos cement factory 1940–82. Br J Ind Med 42: 219–225.
Giaroli C, Belli S, Bruno C, et al. (1994) Mortality study of asbestos cement workers. Int Arch Occup Environ Health 66: 7–11.
Kotela I, Blady-Kotela A (1994) Incidence of mesothelioma among asbestos plant workers. Wiad Lek (Wiadomosci Lekarskie) 47: 161–163 (in Polish).
Sluis-Cremer GK, Liddell FDK, Logan WPD, Bezuidenhout BN (1992) The mortality of amphibole miners in South Africa, 1946– 80. Br J Ind Med 49: 566–575.
Wignall BK, Fox AJ (1982) Mortality of female gas mask assemblers. Br J Ind Med 39: 34–38.
Amandus HE, Wheeler R (1987) The morbidity and mortality of vermiculite miners and millers exposed to tremolite-actinolite: Part II, Mortality. Am J Ind Med 11: 15–26.
Talcott JA, Thurber WA, Kantor AF, Gaensler EA, Danahy JF, Antman KH, Li FP (1989) Asbestos-associated diseases in a cohort of cigarette-filter workers. N Engl J Med 321: 1220–1223.
McDonald JC, McDonald AD, Armstrong B, Sebastien P (1986) Cohort study of mortality of vermiculite miners exposed to tremolite. Br J Ind Med 43: 436–444.
Finkelstein MM (1989) Analysis of mortality patterns and workers' compensation awards among asbestos insulation workers in Ontario. Am J Ind Med 16: 523–528.
Zhu H, Wang Z (1993) Study of occupational lung cancer in asbestos factories in China. Br J Ind Med 50: 1039–1042.
Menegozzo M, Belli S, Bruno C, et al. (1993) Mortality due to asbestos-related causes in a cohort of railway carriage construction workers. Med Lav 84: 193–200 (in Italian).
Blasetti F, Bruno C, Comba P, Fantini F, Grignoli M (1990) Mortality study of workers employed in the construction and maintenance of railway cars. Med Lav 81: 407–413 (in Italian).
Sera Y, Kang K-Y (1981) Asbestos and cancer in the Sennan District of Osaka. Tohoku J Exp Med 133: 313–320.
Morinaga K, Hara I, Yasui I, Yokoyama K, Sera Y (1990) Twenty years' follow-up study of asbestos workers. Jpn J Ind Health 32: 265–268 (in Japanese).
Morinaga K, Hanai A, Fujimoto I, et al. (1991) A retrospective cohort study of workers in small asbestos industries in South Osaka. Jpn J Public Health 38: 267–271 (in Japanese).
Newhouse ML, Sullivan KR (1989) A mortality study of workers manufacturing friction materials: 1941–86. Br J Ind Med 46: 176–179.
Enterline PE, Kendrick MA (1967) Asbestos-dust exposures at various levels and mortality. Arch Environ Health 15: 181–186.
Kleinfeld M, Messite J, Kooyman O (1967) Mortality experience in a group of asbestos workers. Arch Environ Health 15: 177–180.
Mancuso TF, El-Attar AA (1967) Mortality pattern in a cohort of asbestos workers: a study based on employment experience. J Occup Med 9: 147–162.
Mancuso TF (1983) Mesothelioma among machinists in railroad and other industries. Am J Ind Med 4: 501–513.
McDonald AD, Fry JS, Woolley AJ, McDonald JC (1982) Dust exposure and mortality in an American factory using chrysotile, amosite, and crocidolite in mainly textile manufacture. Br J Ind Med 39: 368–374.
Iatsenko AS, Kogan FM (1990) Occupational morbidity and mortality in malignant neoplasms among persons professionally exposed to asbestos dust. Gig Tr Prof Zabol 2: 10–12 (in Russian).
Friedenreich CM (1993) Methods for pooled analyses of epidemiologic studies. Epidemiology 4: 295–302.
Berrino F, Sant M, Verdecchia A, Capocaccia R, Hakulinen T, Estéve J, eds (1995) Survival of Cancer Patients in Europe: The EUROCARE Study (IARC Scientific Publications No. 132). Lyon: International Agency for Research on Cancer.
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Sali, D., Boffetta, P. Kidney cancer and occupational exposure to asbestos: a meta-analysis of occupational cohort studies. Cancer Causes Control 11, 37–47 (2000). https://doi.org/10.1023/A:1008905302597
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DOI: https://doi.org/10.1023/A:1008905302597