Histologic types of epithelial ovarian cancer: have they different risk factors?
Section snippets
Study subjects
Data on reproductive and lifestyle characteristics of White women with invasive epithelial ovarian cancers of serous, mucinous, endometrioid, and clear cell types, and of White control women, were obtained from 10 case-control studies conducted in the United States during the period 1973–2001. Nine of the studies are those with available histology data in the combined analysis of the Collaborative Ovarian Cancer Group (COCG) [1], [2], [3], [4], [5], [6], [7], [8], [9], [10]. The 10th study was
Results
Table 2 shows the distribution of personal characteristics in ovarian cancer patients with each of the four histological cancer types, and in control women. As a group, cases were older than controls, less likely to be parous, to have used oral contraceptives, and to have undergone a tubal ligation, and more likely to report a first-degree relative with breast or ovarian cancer. Patients with the four histologic types of ovarian cancer differed with respect to several of the characteristics.
Discussion
In this study of 1834 cases of invasive epithelial ovarian cancer, little difference was seen among the histologic types with regard to known reproductive factors associated with ovarian cancer risk. All four major histologic types were inversely associated with parity and oral contraceptive use, and all four showed similar association with age at first term pregnancy. With the exception of clear cell carcinoma, all four showed an inverse association with lactation. Other investigators,
Acknowledgments
This research was supported by NIH grants CA94069 and CA71966. The authors thank John Casagrande, Daniel Cramer, Patricia Hartge, Jennifer Kelsey, Joseph Lyon, Philip Nasca, Ralph S. Paffenbarger, Jr., and Noel Weiss for access to data from the Collaborative Ovarian Cancer Group.
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2020, Seminars in Cancer BiologyRisk of high-grade serous ovarian cancer associated with pelvic inflammatory disease, parity and breast cancer
2018, Cancer EpidemiologyCitation Excerpt :It may become cost effective to offer this simple saliva or blood test to more women treated for breast cancer. We also examined the association between parity and risk of HGSC and found a reduced risk of HGSC in women of higher parity (i.e. women with 3 or more births, compared with women with 0, 1 or 2 births), consistent with most studies of serous [8,9,11,12,16,17,19,21,26,28–31] and high-grade serous [19,30] ovarian carcinoma, but not all. Some studies did not find an association with serous [14,28] or high-grade serous [14] carcinoma.