Predictive value of indexes of inflammation and hypercoagulability on success of cardioversion of persistent atrial fibrillation

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Abstract

The aim of the present study was to investigate whether success or failure of direct-current cardioversion in patients with persistent atrial fibrillation may be related to indexes of inflammation (as indicated by C-reactive protein and interleukin-6, platelet activation [soluble P-selectin levels], endothelial damage/dysfunction [von Willebrand factor], coagulation cascade [tissue factor and fibrinogen], and rheology [plasma viscosity and hematocrit]). We found that C-reactive protein levels are a predictor of initial cardioversion success, although they failed to predict long-term outcome. Although inflammation may be associated with “permanence” of atrial fibrillation, indexes of platelet activation, endothelial damage/dysfunction, or coagulation showed no relation to the immediate and long-term (2-month) cardioversion outcome.

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Acknowledgements

We thank Andrew Makin, MD, and Bethan Freestone, MRCP, for help with data collection.

References (1)

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    (2001)

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This study was supported in part by the Dowager Countess Eleanor Peel Trust and the Sandwell and West Birmingham Hospitals NHS Trust Research and Development programme.

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