Re-wetting, comfort, lubricant and moisturising solutions for the contact lens wearer
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Cited by (16)
Interfacial polymerization of a thin film on contact lenses for improving lubricity
2020, Journal of Colloid and Interface ScienceCitation Excerpt :A large number of patients still experience discomfort and dryness in spite of the significant improvements through surface treatments and incorporation of comfort agents in contact lenses. A possible explanation for the persisting symptoms is that the absorbed wetting agents desorb with time, leading to the reduced end of day comfort [20]. Furthermore, preservative agents and buffers included in the care solutions can trigger allergic reactions and solution induced corneal staining (SICS) [21–26].
Improving wettability and lubricity of commercial contact lenses by polymerizing a thin film of dimethylacryamide
2019, Colloids and Surfaces A: Physicochemical and Engineering AspectsCitation Excerpt :Chauhan et al. also explored incorporation of surfactants in contact lenses to improve lubricity [35]. However, the lens comfort is significantly reduced by the end of the day due to desorption of the absorbed and adsorbed surfactant [36]. Alcon has recently commercialized a water gradient contact lens that has a thin film of high water content polymer on the surface [37,38].
Incorporation of polymerizable surfactants in hydroxyethyl methacrylate lenses for improving wettability and lubricity
2015, Journal of Colloid and Interface ScienceCitation Excerpt :Addition of surfactants in rewetting drops and lens care solutions has been found to be beneficial most likely due to improved wettability of the surface due to surfactant adsorption [15,16]. The adsorbed and absorbed surfactant however desorbs with time, possibly leading to the reduced end of day comfort [17]. Also, the preservatives included in the formulations can absorb into the lenses and then desorb during lens wear which could lead to patient discomfort and potential toxicity issues [18–21].
Fluorescein-tear breakup time as an assessment of efficacy of tear replacement therapy in dry eye patients: A systematic review and meta-analysis
2014, Ocular SurfaceCitation Excerpt :While the related terminology has broadened somewhat over the years, with “damage” replacing the once widely used term “desiccation” (i.e., dryness of the ocular surface), the overall consequence of dry eye disease is still that the normal interface between the tear film and the surface epithelia is likely to be compromised.8-10 The damage could be in the microplicae that constitute part of the surface of both the corneal epithelial cells11 and bulbar conjunctival cells,12 or in the glycocalyx associated with these surface structures.13,14 Mucus, largely derived from conjunctival goblet cells, produces the interface interacting with the cell surfaces and the aqueous phase of the tear film.
Bringing comfort to the masses: A novel evaluation of comfort agent solution properties
2014, Contact Lens and Anterior EyeCitation Excerpt :Contact lens induced dry eye (CLIDE) and contact lens associated discomfort (CLAD) complaints lead to decreased contact lens use and patient dissatisfaction with contact lenses [27–30]. Incorporating comfort agents into contact lenses prevents lens dehydration [31–34], reduces protein adhesion rates [35–40], maintains surface wettability and lubrication [37,41], decreases surface friction and tension [42–44], and has other effects [44]. It has been well documented that frequent application of comfort agent-containing eye drops can greatly increase the level of comfort perceived by consumers [15,16,23,41,45–61], though little work has been conducted to isolate the effects of comfort agent species, molecular weight, percent concentration, and dosage on the efficacy of comfort agents.
Objective clinical performance of 'comfort-enhanced' daily disposable soft contact lenses
2010, Contact Lens and Anterior Eye