REVIEW ARTICLESThe role of endotoxin and its receptors in allergic disease
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Cited by (76)
Indoor metabolites and chemicals outperform microbiome in classifying childhood asthma and allergic rhinitis
2023, Eco-Environment and HealthIndoor microbiome and allergic diseases: From theoretical advances to prevention strategies
2022, Eco-Environment and HealthA Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children
2022, Ecotoxicology and Environmental SafetyCitation Excerpt :Well-functioning immune regulation and immune tolerance and low incidence of immune-mediated diseases has been reported to be associated with living next to agricultural areas and green space (Hanski et al., 2012; Kirjavainen et al., 2019; Nurminen et al., 2021). Similarly, people following traditional lifestyles with abundant contacts with environmental microbiota typically have diverse commensal microbiota and low incidences of immune-mediated diseases (Alfven et al., 2006; Kondrashova et al., 2013; Lee et al., 2012; Stein et al., 2016; Williams et al., 2005). On the other hand, agricultural environment may enrich bacteria, such as Thermoactinomyces vulgaris, T. viridis and T. sacchari, that have been associated with inflammatory reactions and eventually hypersensitivity pneumonitis (Nogueira et al., 2019).
House dust microbiota in relation to adult asthma and atopy in a US farming population
2021, Journal of Allergy and Clinical ImmunologyExposure and Sensitization to Pets Modify Endotoxin Association with Asthma and Wheeze
2018, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :In animal studies, endotoxin aggravated inflammation caused by allergen challenge in rats previously sensitized. However, when exposure to endotoxin precedes sensitization, it seems to alleviate allergen-induced airway hyperresponsiveness.30,31 This is coherent with a stronger effect of endotoxin on the risk of asthma in participants previously sensitized to cats or exposed to higher concentration of cat and dog allergens in their homes.
This work was supported in part by grants from the National Institute of Allergy and Infectious Diseases (R01AI61774, R01AI50681) and the Fund for Henry Ford Hospital.