Elsevier

Reproductive Toxicology

Volume 11, Issue 5, September–October 1997, Pages 719-750
Reproductive Toxicology

Special contribution
Endocrine screening methods workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms

https://doi.org/10.1016/S0890-6238(97)00025-7Get rights and content

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References (194)

  • A Cummings

    Toxicological mechanisms of implantation failure

    Fundam Appl Toxicol

    (1990)
  • A Cummings et al.

    Antifertility effects of methoxychlor in female rats. A time-dependent blockade of pregnancy

    Toxicol Appl Pharmacol

    (1989)
  • SC Brooks et al.

    Estrogen receptor in a human cell line (MCF-7) from breast carcinoma

    J Biol Chem

    (1973)
  • KB Horwitz et al.

    MCF-7: a human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors

    Steroids

    (1975)
  • JA Eisman et al.

    1,25-Dihydroxyvitamin D3 receptor in a cultured human breast cancer cell line (MCF-7 cells)

    Biochem Biophys Res Commun

    (1980)
  • CM Taylor et al.

    A simple method to determine whole cell uptake of radiolabelled oestrogen and progesterone and their subcellular localization in breast cancer cell lines in monolayer culture

    J Steroid Biochem

    (1984)
  • U Mayr et al.

    Validation of two in vitro test systems for estrogenic activities with zearalenone, phytoestrogens and cereal extracts

    Toxicology

    (1992)
  • AK Wakeling et al.

    Novel antioestrogens without partial agonist activity

    J Steroid Biochem

    (1988)
  • AE Wakeling et al.

    ICI 182,780, a new antioestrogen with clinical potential

    J Steroid Biochem Mol Biol

    (1992)
  • AM Soto et al.

    Mechanism of estrogen action on cellular proliferation: evidence for indirect and negative control on cloned breast tumor cells

    Biochem Biophys Res Commun

    (1984)
  • AM Soto et al.

    A plasma-borne specific inhibitor of the proliferation of human estrogen-sensitive breast tumor cells (estrolycone-I)

    J Steroid Biochem Mol Biol

    (1992)
  • WV Welshons et al.

    Adaptation of estrogen-dependent MCF-7 cells to low estrogen (phenol red-free) culture

    Eur J Cancer Clin Oncol

    (1987)
  • H Nawata et al.

    Estradiol-independent growth of a subline of MCF-7 human breast cancer cells in culture

    J Biol Chem

    (1981)
  • J Kitawaki et al.

    Growth suppression of MCF-7 human breast cancer cells by aromatase inhibitors: a new system for aromatase inhibitor screening

    J Steroid Biochem Mol Biol

    (1993)
  • D.M. Klotz et al.

    Differential expression of wild-type and variant ER mRNAs by stocks of MCF-7 breast cancer cells may account for differences in estrogen responsiveness

    Biochem Biophys Res Commun

    (1995)
  • W.B. Butler

    Preparing nuclei from cells in monolayer cultures suitable for counting and for following synchronized cells through the cell cycle

    Anal Biochem

    (1984)
  • P Mellanen et al.

    Wood-derived estrogens: studies in vitro with breast cancer cell lines and in vivo in trout

    Toxicol Appl Pharmacol

    (1996)
  • P.T. Jain et al.

    Cell-growth quantitation methods for the evaluation of antiestrogens in human breast cancer cells in culture

    J Pharmacol Toxicol Methods

    (1992)
  • R Kavlock et al.
  • AG Gillman

    Goodman & Gillman's The Pharmacological basis of therapeutics

    (1990)
  • E Allen et al.

    The induction of a sexually mature condition in immature females by injection of the ovarian follicular hormone

    Am J Physiol

    (1924)
  • L Hershberger et al.

    Myotrophic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method

  • E Dodds et al.

    Biological effects of the synthetic oestrogenic substance 4:4′-dihydroxy-α:B-diethylstilbene

    Lancet

    (1938)
  • S Laws et al.

    4-Tert-octylphenol: in vitro and in vivo assessments of potential estrogenicity in rats

    Toxicologist

    (1995)
  • B Gillesby et al.

    Endocrine disrupters: mechanism of action of promiscuous receptors and strategies for identification and assessment [abstract]

  • Gray LE. Organizational and activational effects of pesticides and toxic substances on the CNS and behavior: endocrine...
  • J Reel et al.

    Evaluation of a new reproductive toxicology protocol using diethylstilbestrol (DES) as a positive control compound

    J Am Coll Toxicol

    (1985)
  • J Conner et al.

    An in vivo battery for identifying endocrine modulators that are estrogenic or dopamine regulators

    Fundam Appl Toxicol

    (1996)
  • V Salamon

    The effect of testosterone propionate on the genital tract of the immature female rat

    Endocrinology

    (1938)
  • K Nelson et al.

    Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation

  • wood R Hey et al.

    The experimental toxicology of estrogens

    Pharmacol Ther

    (1980)
  • G Morali et al.

    Neuroendocrine control of mammalian estrous behavior

  • K Larsson

    Features of the neuroendocrine regulation of masculine sexual behavior

  • W Young et al.

    The ovarian hormones and spontaneous running activity in the female rat

    Endocrinology

    (1945)
  • K Miyazaki et al.

    Dopaminergic modulation of DES-induced proliferation of the anterior pituitary of the Fisher 344 rat

    Neuroendocrinology

    (1985)
  • S Anderson et al.

    Validation of the alternative reproductive test protocol (ART) to assess toxicity of methoxychlor in rats

    Toxicologist

    (195)
  • J Toppari et al.

    Male reproductive health and environmental xenoestrogens

    Envison Health Perspect

    (1996)
  • B Robaire et al.

    Interactions of testosterone and estradiol-17β on the reproductive tract of the male rat

    Biol Reprod

    (1979)
  • T Iguchi

    Cellular effects of early exposure to sex hormones and antihormones

    Int Rev Cytol

    (1992)
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    The research described in this article has been reviewed by the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

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