INCREASED FREQUENCY OF THYROID AUTOANTIBODIES IN MOTHERS OF PATIENTS WITH DOWN'S SYNDROME - ScienceDirect

The Lancet

Volume 286, Issue 7418, 30 October 1965, Pages 868-870

The Lancet

https://doi.org/10.1016/S0140-6736(65)92502-X Get rights and content

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Cited by (30)

Down's syndrome, interferon sensitivity and the development of leukaemia
1994, Leukemia Research
I suggest that the occurrence of transient leukemoid reactions, myelofibrosis and leukaemia in Down's syndrome may all result from the greatly increased sensitivity of Down's syndrome cells to interferon with consequent aberrant antigen expression leading to auto-immune disease. In the bone marrow this may manifest itself as premature egress of blast cells (TLR), inflammation and imperfect repair (myelofibrosis), and the binding of autoantibodies to cell nuclei resulting in malignant transformation leading to leukaemia. Therapy consistent with this hypothesis would be directed at blocking the effects of gamma interferon, and such therapy might also be useful in certain forms of leukaemia associated with viral infection.
Malignant lymphoma of the thyroid
1981, Clinics in Endocrinology and Metabolism
Increasing Prevalence of Congenital Hypothyroidism in children with Down Syndrome who have a family history of Thyroid disease
2023, Research Journal of Pharmacy and Technology
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Family history of thyroid disease and risk of congenital hypothyroidism in neonates with down syndrome
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Prevalence and risk factors for Down syndrome: A hospital-based single-center study in Western Mexico
2019, American Journal of Medical Genetics, Part A

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¹: Present address: department of pediatrics, University of Oregon Medical Center, Portland, Oregon, U.S.A.

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