Specific IgG, but not specific IgE, antibodies to toluene diisocyanate–human serum albumin conjugate are associated with toluene diisocyanate bronchoprovocation test results☆,☆☆,★
Section snippets
Subjects
Fifty subjects with TDI-induced asthma were classified as group 1. Their bronchial sensitization was confirmed by positive responses to TDI bronchoprovocation tests (BPTs): 23 had early, 5 had late only, 9 had dual, and 13 had atypical asthmatic responses, including progressive, prolonged immediate, and square-shaped responses. Thirteen subjects who had worked in the same place with exposure to TDI and complained of lower respiratory symptoms but had negative responses on TDI BPT were
Specific IgG antibody to TDI-HSA conjugate
Fig 1 demonstrates the prevalence of specific IgG antibody to TDI-HSA conjugate in 4 different groups.
DISCUSSION
Several groups of investigators have detected various prevalences of specific IgE antibody to TDI-HSA conjugate in the sera of workers with positive challenge results; the prevalence varied between 0% and 50% of the workers.1, 2, 5, 6 In this study 7 (14%) of the subjects with TDI-induced asthma had high specific IgE antibody levels, whereas one (7.7%) in group 2 and none in the unexposed subjects or healthy control subjects had similarly high specific IgE antibody levels. These findings
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Serum specific IgG response to toluene diisocyanate-tissue transglutaminase conjugate in toluene diisocyanate-induced occupational asthmatics
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Supported by International Isocyanate Institute grant number 145-AP-MIX (1998).
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Reprint requests: Hae-Sim Park, MD, Associate Professor, Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Paldalgu Wonchondong San-5, Suwon, Korea.
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