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Multipoint genetic mapping with trisomy data
2001, American Journal of Human GeneticsCitation Excerpt :The objective of the present article is to develop general statistical approaches that overcome the limitations of the existing methods for the analysis of trisomy data. Genetic mapping methods for nondisjoined chromosomes have been discussed by Ott et al. (1976), Shahar and Morton (1986), Chakravarti and Slaugenhaupt (1987), Chakravarti et al. (1989), Feingold et al. (2000), Yu and Feingold (2001), and other researchers. In most studies, genetic map construction is divided into two steps.
Multipoint estimation of genetic maps for human trisomies with one parent or other partial data
2000, American Journal of Human GeneticsCitation Excerpt :A completely informative marker provides unequivocal information about whether the two chromosomes are R or N at the locus. If all markers are completely informative, creating a genetic map is straightforward under the assumption of no interference (e.g., Chakravarti and Slaugenhaupt 1987), and can also be handled under a χ2 model of interference (Zhao and Speed 1998). Unfortunately, not all markers are fully informative in typical human data.
Parental origin and phenotype of triploidy in spontaneous abortions: Predominance of diandry and association with the partial hydatidiform mole
2000, American Journal of Human GeneticsCitation Excerpt :However, to more formally distinguish between mechanisms by means of this approach, we developed a likelihood method to determine the most likely mechanism of origin. Our approach was similar to that of Jacobs and Morton (1977) for chromosome heteromorphism studies of polyploidy, but our approach was modified to take into account the effect of recombination, as detailed by Chakravarti and Slaugenhaupt (1987). Additionally, since the majority of our cases involved “incomplete” families, the method was modified accordingly (see Appendix).
Multipoint genetic mapping with uniparental disomy data
2000, American Journal of Human GeneticsCitation Excerpt :The objective of the present article is to develop a general statistical approach that overcomes the limitations of the existing methods in the analysis of UPD data. Genetic-mapping methods for nondisjoined chromosomes have been discussed by Shahar and Morton (1986), Chakravarti and Slaugenhaupt (1987), Chakravarti et al. (1989), Feingold et al. (2000), and other researchers. In most studies, genetic-map construction is divided into two steps.
12 Nondisjunction in the Human Male
1997, Current Topics in Developmental BiologyLikelihood ratio formulae for disputed parentage when the product of conception is trisomic
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