Elsevier

Toxicology Letters

Volume 44, Issues 1–2, November 1988, Pages 109-112
Toxicology Letters

Urinary atrazine metabolites as indicators for rat and human exposure to atrazine

https://doi.org/10.1016/0378-4274(88)90136-1Get rights and content

Abstract

Rats were given atrazine (2-chloro-4-ethylamino-6-(isopropylamino)-s-triazine) in drinking water for 1 or 3 weeks at 0.1 (0.45 mM), 0.2 (0.9 mM) or 0.5 g/l (2.3 mM) concentrations of the commercial agent. They excreted at both time points as the principal metabolite 2-chloro-4-ethylamino-6-amino-s-triazine in a dose-dependent fashion. The same urine test was applied on 6 railway men engaged in the weeding operation of railway lines with known atrazine exposure measured with hygienic techniques in their breathing zone. The spectrum of their atrazine metabolites was comprised of fully N-dealkylated atrazine and 2-chloro-4-ethylamino-6-amino-s-triazine. The sum of the two urinary metabolites reflected quantitatively the exposure.

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    Citation Excerpt :

    They found considerably higher amounts of urinary ATR and its metabolites in applicators and their families living on the farm. The metabolism of ATR has been studied in different species (Bakke et al., 1972; Ikonen et al., 1988; Catenacci et al., 1990; McMullin et al., 2003; Ross and Filipov, 2006). Major ATR metabolites reported in mammals and humans are desethyl atrazine (DE), desiopropyl atrazine (DIP), and didealkyl atrazine (DACT; Bakke et al., 1972; Erickson et al., 1979; Catenacci et al., 1993; McMullin et al., 2003; Ross and Filipov, 2006).

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