Brain dopamine as a target for solvent toxicity: Effects of some monocyclic aromatic hydrocarbons
References (11)
- et al.
Arch. Toxicol.
(1984) - et al.
Arch. Toxicol.
(1985) - et al.
Scand. J. Work, Environ. Health
(1984) - et al.
J. Occup. Med.
(1987) - et al.
J. Appl. Toxicol.
(1986)
Cited by (53)
Indoor VOCs exposure induced Parkinson-like behaviors through autophagy dysfunction and NLRP3 inflammasome-mediated neuroinflammation
2022, Journal of Hazardous MaterialsCitation Excerpt :Moreover, exposure to formaldehyde induces neuronal metabolic disturbances by inducing acceleration of glycolytic flux and multidrug resistance protein 1-mediated rapid glutathione export from astrocytes and neurons (Tulpule and Dringen, 2013). Brain dopamine depletion has also been reported with exposure to styrene or styrene metabolites (Mutti et al., 1988). Additionally, some studies demonstrate that the pathogenesis of PD involves multiple related processes such as neuroinflammation, oxidative stress and mitochondrial dysfunction (Subramaniam and Chesselet, 2013; Whitton, 2007).
Synaptic contacts impaired by styrene-7,8-oxide toxicity
2007, Toxicology and Applied PharmacologyAnalysis of oxidative stress in SK-N-MC neurons exposed to styrene-7,8-oxide
2005, Toxicology in VitroCitation Excerpt :Alternative explanations to styrene neurotoxicity have been put forward by our group years ago. Brain dopamine depletion has been reported upon exposure to styrene or styrene metabolites in experimental studies (Mutti et al., 1984b, 1988), and the dopaminergic system has been suggested as a specific target for styrene neurotoxicity both in humans (Mutti et al., 1984a; Arfini et al., 1987; Mutti and Franchini, 1987) and laboratory animals (Mutti et al., 1984b, 1988). SO at high doses has been shown to be neurotoxic in animals and using in vitro models (Katoh et al., 1989; Trenga et al., 1991; Kohn et al., 1995; Beiswanger et al., 1993; Chakrabarti, 1999) and the mechanisms by which it acts are still unclear.
Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells
2002, Brain ResearchCitation Excerpt :Styrene is known to alter neurotransmission in the brain [15,20]. Decreased levels of dopamine in rabbit brain tissue and impairment of the dopamine transport in rat striatal synaptic vesicles have been reported [4,28,29], suggesting a possible dopamine-mediated effect of styrene neurotoxicity. In rats sub-chronically exposed to styrene vapors, a reduced density of retinal amacrine cells associated with dopamine depletion confirmed the vulnerability of dopaminergic systems to styrene toxicity, providing some insights on the possible mechanism of loss in chromatic discrimination recorded among workers exposed to styrene [46].