Subchronic nose-only inhalation study of propylene glycol in Sprague-Dawley rats☆
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Considerations for deriving a safe intake of propylene glycol
2024, Food and Chemical ToxicologyConventional and multi-omics assessments of subacute inhalation toxicity due to propylene glycol and vegetable glycerin aerosol produced by electronic cigarettes
2024, Ecotoxicology and Environmental SafetyVAPIng into ARDS: Acute Respiratory Distress Syndrome and Cardiopulmonary Failure
2022, Pharmacology and TherapeuticsCitation Excerpt :A prescient study assessing nebulized PG inhalation (without heating) concluded there was no evidence for systemic toxicity but significant increases in mucin content of existing goblet cells as well as increased number of goblet cells in nasal turbinates.( Suber, Deskin, Nikiforov, Fouillet, & Coggins, 1989) Decades later, increased mucin levels consequential to PG/VG fluid exposure was noted in cell cultures of human nasal epithelia (Escobar et al., 2021), murine nasal epithelia, and human airway epithelia.( Ghosh et al., 2018) Disruption of lipid homeostasis in a murine inhalation model using a commercially sourced ENDS device prompted lipid accumulation in alveolar macrophages and type II pneumocytes.(
Influence of collection and storage materials on glycol ether concentrations in urine and blood
2021, Science of the Total EnvironmentCitation Excerpt :Materials used to collect and store blood and urine are mainly made of three common polymer plastics, such as polypropylene (PP), polyethylene (PE) or polystyrene (PS) (Boeynaems et al., 2004; Bowen et al., 2005; Bowen and Remaley, 2014; Kratz et al., 2006). For instance, in biomonitoring and toxicological studies with glycol ethers, the material used was either polyethylene (Corley et al., 1997; Devanthéry et al., 2000; Moffatt et al., 1986) or glass (Domoradzki et al., 2003), or was even not reported (Angerer et al., 2002; Devanthéry et al., 2002; Hubner et al., 1992; Johanson et al., 1986; Juenke et al., 2011; Livesey et al., 1995; Morgott and Nolan, 1987; Robertson and Loosli, 1947; Smallwood et al., 1984; Starek et al., 2010; Suber et al., 1989). Glycol ethers is a family of 80 chemicals that may be reprotoxic and neurotoxic (Fowles et al., 2017; Institut national de la santé et de la recherche médicale, 2005; Institut National de Recherche et de Sécurité, 2012; Landry et al., 1983; Lemazurier et al., 2003; US EPA, n.d.; Welsch, 2005).
Electronic cigarettes as a harm reduction concept for public health
2021, Toxicological Risk Assessment and Multi-System Health Impacts from Exposure
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Presented, in part, at the 26th Annual Meeting of the Society of Toxicology, February 1987, Washington, DC.
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Current address: American Cyanamid, Wayne, NJ 07470, USA.
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Current address: Exxon Biomedical Sciences, East Millstone, NJ 08875-2350, USA.