ORIGINAL ARTICLESMutations of p53 and ras genes in radon-associated lung cancer from uranium miners
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Cited by (296)
Genetic damage in coal and uranium miners
2021, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :The attention to the possibility of damage to genetic material of these workers is intrinsically related to the fact that ionizing radiation was the first recognized factor with mutagenic properties [43]. Ionizing radiation cause numerous of genetic damage including oxidation of DNA bases, generation of single-strand breaks and double-strand breaks, base modifications and protein-DNA crosslinks [44,45]. Concerns’ regarding the exposure of uranium miners to ionizing radiation is not only due to uranium itself, but also to its decay products, mainly radon and radon progeny, which are well-known human lung carcinogens according to IARC [46].
Multistage Carcinogenesis: Cell and Animal Models
2018, Comprehensive Toxicology: Third EditionRadioactively contaminated areas: Bioindicator species and biomarkers of effect in an early warning scheme for a preliminary risk assessment
2016, Journal of Hazardous MaterialsMechanisms of mutagenesis: DNA replication in the presence of DNA damage
2016, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :Animals have produced tumors after exposure to many environmental mutagens [3]. Human exposure to specific chemical or physical carcinogens also produces characteristic mutational spectra, considered to be highly relevant not only to cancer but also to cardiovascular disease, teratology, and aging [4–6]. Therefore, studies on how chemicals can lead to mutations have received considerable attention.
Investigating uranium distribution in surface sediments and waters: A case study of contamination from the Juniper Uranium Mine, Stanislaus National Forest, CA
2014, Journal of Environmental RadioactivityCitation Excerpt :Prolonged exposure to moderate or high levels of uranium such as exist in ore-grade deposits can be harmful to plants, wildlife, and human populations (Ansoborlo et al., 2006; ATSDR, 1999; Craft et al., 2004). Uranium and its daughter products of decay have been shown to cause genetic mutation and are known carcinogens (ATSDR, 1999; Coryell and Stearns, 2006; Vahakangas et al., 1992). Attempts to limit biological exposure to uranium drive a scientific interest in determining how uranium moves and where it is stored and released in nature.
Combined exposure to X-irradiation followed by N-ethyl-N-nitrosourea treatment alters the frequency and spectrum of Ikaros point mutations in murine T-cell lymphoma
2012, Mutation Research - Fundamental and Molecular Mechanisms of MutagenesisCitation Excerpt :Molecular epidemiological data for human cancers have been analyzed to establish causation, and several chemical carcinogen signatures have been identified [43–46]. However, only a limited number of controversial radiation signatures have been reported in human cancers, such as a p53 mutation in lung tumors of miners heavily exposed to radon [47] and a possible distinct pattern of RET oncogene rearrangement in post-Chernobyl thyroid tumors [48]. Here we demonstrated the alteration of the mutation spectrum in lymphomas after combined exposure to X-rays and ENU compared with exposure to one carcinogen alone.
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Present address: Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland.