Cardiac function study in hard metal workers
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Metals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States
2022, Environmental ResearchCitation Excerpt :The cardiovascular effects of cobalt, in contrast, have been more extensively examined in occupational settings. Epidemiologic studies in highly occupationally exposed populations have found associations of cobalt exposure with cardiovascular endpoints, including altered diastole, reduced left ventricular systolic function, left ventricular and atrial hypertrophy, reversible electrocardiographic changes, arrhythmias, and hypertension (D'Adda et al., 1994; Horowitz et al., 1988; Leyssens et al., 2017; Linna et al., 2004; Machado et al., 2012; Oldenburg et al., 2009). Cobalt appears to exert toxic effects through the inhibition of cellular respiration due to interruption of the mitochondrial function (Leyssens et al., 2017).
Effects of CoCr metal wear debris generated from metal-on-metal hip implants and Co ions on human monocyte-like U937 cells
2015, Toxicology in VitroCitation Excerpt :Co corrodes faster than Cr under physiological conditions (Xia et al., 2011) and, in contrast to Cr, Co ions tend to remain mobile, which is reflected in the higher levels measured in blood, allowing the ions to reach and enter remote organs (Afolaranmi et al., 2012). Elevated Co concentrations in patients with MoM implants are a concern, since increased Co levels in blood have also been reported to be associated with neurological (hand tremor, incoordination, cognitive decline, depression, vertigo, hearing loss, and visual changes) (Oldenburg et al., 2009; Tower, 2010), cardiac (myocardiopathy) (Dadda et al., 1994; Seghizzi et al., 1994; Gilbert et al., 2013) and endocrine (aberrant oestrogen signalling, altered the production or circulation of sex hormones, and altered thyroid metabolism) (Keegan et al., 2007; Oldenburg et al., 2009) symptoms. In addition to the above, data from the seventh annual report of the National Joint Registry for England and Wales showed high failure rates for MoM hip prostheses (http://www.njrcentre.org.uk/njrcentre/portals/0/njr%207th%20annual%20report%202010.pdf), which led to the market recall of the DePuy ASRTM, both the Resurfacing and XL Systems in August 2010 (DePuy International Ltd., Leeds, UK) (MDA/2010/069).
The European congress on cobalt and hard metal disease. Conclusions, highlights and need of future studies
1994, Science of the Total Environment, TheCobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes
2021, Particle and Fibre ToxicologyEffects of occupational cobalt exposure on the heart in the production of cobalt and cobalt compounds: a 6-year follow-up
2020, International Archives of Occupational and Environmental HealthThe analysis of the dimple arrangement of the artificial hip joint to the performance of lubrication
2019, IOP Conference Series: Materials Science and Engineering