Effects of short-term benzene administration on bone marrow cell cycle kinetics in the rat☆
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Pesticide induced marrow toxicity and effects on marrow cell population and on hematopoietic stroma
2013, Experimental and Toxicologic PathologyCitation Excerpt :There are evidences of drug induced damage of hematopoietic microenvironment in aplastic anemia in humans, but the co-relation between pesticide toxicity and microenvironmental damage is not quite steadily explained. The investigation of the mechanism of pesticide toxicity has often focused on pesticide induced inhibition of cell proliferation in in vitro culture condition (Irons et al., 1979; Rio et al., 1997; Rugman and Cosstick, 1990). Data on isolated parameters and in vitro evaluation of toxicity are difficult to use as gold standard since the bone marrow is extremely complex in nature with close association and inter-dependence on various cell types, and an essential microenvironment.
Biomonitoring Equivalents for benzene
2012, Regulatory Toxicology and PharmacologyCitation Excerpt :Once in the bone marrow, and perhaps in the peripheral circulation as well, it appears that the various metabolites interact with either mature blood cells or early precursor cells that would ultimately produce mature blood cells (Baarson et al., 1984). The toxicity of benzene has been shown to be greater in rapidly dividing cells, where more actively dividing cells are targeted but quiescent hematopoietic stem cells are spared (Dempster and Snyder, 1990, 1991; Green et al., 1981; Irons, 1981; Irons et al., 1979a; Keller and Snyder, 1988; Longacre et al., 1980). Additional evidence indicates that benzene metabolites can induce a block in cell cycle as well as induce apoptosis in precursor cells (Ross et al., 1996; Yoon et al., 2001).
Low level occupational benzene exposure and hematological parameters
2010, Chemico-Biological InteractionsCitation Excerpt :Data from animal studies indicate that decreases in the number of red blood cells, total number of white blood cells, and hemoglobin levels are not the most sensitive indicators of early benzene effects on blood cells. In animal models, peripheral lymphocytes are among the most sensitive cells, with decreases in peripheral counts of circulating lymphocytes appearing before other hematological effects [4–6,7]. Decreased lymphocyte counts are an early and consistent finding in workers in whom benzene toxicity was evident, and there is evidence that the conditions disappear when the worker is removed from benzene exposure [8].
Mechanism of action of benzene toxicity: Cell cycle suppression in hemopoietic progenitor cells (CFU-GM)
2001, Experimental HematologyIndicators of immunotoxicity in populations of cotton rats (Sigmodon hispidus) inhabiting an abandoned oil refinery
1999, Ecotoxicology and Environmental SafetyBenzene-induced hematotoxicity and bone marrow compensation in B6C3F1 mice
1997, Fundamental and Applied Toxicology
- ☆
Preliminary results of this study were reported at the Joint Meeting American Society for Pharmacology and Therapeutics and the Society of Toxicology (1978), Houston, Tex.
- 3
Chemical Industry Institute of Toxicology, Department of Pathology and Biochemical Toxicology, P.O. Box 12137, Research Triangle Park, N.C. 27709.
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Department of Pathology, University of Rochester Medical Center, 560 Elmwood Avenue, Rochester, N.Y. 14642.