Lead and δ-aminolevulinic acid concentrations in human parotid saliva

doi:10.1016/0041-008X(74)90028-3

Toxicology and Applied Pharmacology

Volume 27, Issue 3, March 1974, Pages 491-493

https://doi.org/10.1016/0041-008X(74)90028-3 Get rights and content

Abstract

Quantitative values of lead and δ-aminolevulinic acid in normal human parotid saliva were determined and were found to be 3.1 (±0.5) and 10.2 (±0.6) μg/100 ml, respectively. The relationship of salivary lead concentration to blood lead concentration was examined. For the experimental population studied, parotid saliva was estimated to contain approximately 13% of the blood lead concentration. No significant difference was found between parotid saliva and plasma δ-aminolevulinic acid concentrations.

References (14)

S. Dreizen et al.
Comparative concentrations of selected trace metals in human and marmoset saliva
Arch. Oral. Biol.
(1970)
H.J. Eichel et al.
Acid and alkaline ribonucleases of human parotid, submaxillary, and whole salivas
Arch. Biochem. Biophys.
(1964)
J.C. Aub et al.
Lead poisoning
Medicine (Baltimore)
(1925)
D. Barltrop et al.
Interaction of lead with erythrocytes
Experientia
(1971)
A.S.V. Burgen et al.
E.M. Butt et al.
Trace metal levels in human serum and blood
Arch. Environ. Health
(1964)
H.T. Delves
A micro-sampling method for the rapid determination of lead in blood by atomic absorption spectrophotometry
Analyst (London)
(1970)

There are more references available in the full text version of this article.

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Lead and δ-aminolevulinic acid concentrations in human parotid saliva

Abstract

Arch. Oral. Biol.

Arch. Biochem. Biophys.

Lead poisoning

Medicine (Baltimore)

Interaction of lead with erythrocytes

Experientia

Trace metal levels in human serum and blood

Arch. Environ. Health

A micro-sampling method for the rapid determination of lead in blood by atomic absorption spectrophotometry

Analyst (London)