Computation of exact confidence intervals for the odds ratio

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Abstract

A time-sharing program written in BASIC language has been developed to compute exact confidence limits for the odds ratio parameter in a 2 × 2 table. The program offers the user a choice between the classical exact limits and limits based upon a recent redefinition of the exact p-value aimed at avoidance of conservatism in the classical procedure. The user selects the degree of confidence desired during a run of the program, which then computes the exact limits and p-value.

Résumé

On a développé un programme time-sharing écrit en langage BASIC qui calcule les limites de confiance exactes pour le paramètre de raison des chances (odds ratio) dans un tableau 2 × 2. Le programme présente à l'utilisateur un choix entre les limites exactes classiques et les limites basées sur une redéfinition récente de la valeur exacte de p pour éviter le conservatisme de l'utilisateur en la procédure classique. L'utilisateur sélectionne le degré de confiance désiré pendant le programme, lequel ensuite calcule les limites exactes et la valeur de p.

References (4)

  • J.J. Gart

    The comparison of proportions: A review of significance tests, confidence intervals and adjustments for stratification

    Rev. Int. Stat. Inst.

    (1971)
  • A.L. Herbst et al.

    Adenocarcinoma of the vagina

    New Eng. J. Med.

    (1971)
There are more references available in the full text version of this article.

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This work was supported by Public Health Service Research Grant No. 5 P01 CA 06373 from the National Cancer Institute.

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