New concepts in the pathogenesis and treatment of noninsulin-dependent diabetes mellitus☆
References (310)
- et al.
Dose-response relation between plasma insulin and blood-glucose levels during oral glucose loads in prediabetic and diabetic subjects
Lancet
(1973) - et al.
Nonketotic diabetes mellitus: insulin deficiency or insulin resistance?
Am J Med
(1976) - et al.
Early response to glucose and to tolbutamide in maturity onset diabetes
Metabolism
(1970) - et al.
Chemical diabetes in the juvenile patient
Metabolism
(1973) - et al.
Insulin patterns prior to and after onset of diabetes
Metabolism
(1969) - et al.
Diabetes, blood lipids, lipoproteins, and change of environment: restudy of the “New Immigrant Yemenites in Israel.”
Metabolism
(1979) Normal initial plasma insulin response in mild diabetes
Metabolism
(1972)Criteria for interpretation of the oral glucose tolerance tests in children and insulin responses with normal and abnormal tolerance
Metabolism
(1973)- et al.
The intravenous glucose tolerance test in chemical diabetes
Metabolism
(1973) I. Identification of chemical diabetes. The definition of chemical diabetes
Metabolism
(1973)
Relationship between the plasma glucose level and glucose uptake in the conscious dog
Metabolism
Oral glucose tolerance test: effect of different glucose loads on splanchnic carbohydrate and substrate metabolism in healthy man
Metabolism
The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man
Metabolism
Lack of a gastrointestinal mediator of insulin action in maturity-onset diabetes
Lancet
Hepatic parasympathetic neuropathy as cause of maturity-onset diabetes?
Gen Pharmacol
Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects
J Clin Invest
Decreased sensitivity of the pancreatic beta cells to glucose in prediabetic and diabetic subjects . A glucose dose-response study
Diabetes
Hyperinsulinemia and hypoinsulinemia. Insulin responses to oral carbohydrate over a wide spectrum of glucose tolerance
Diabetes
Mild diabetes in young subjects. Clinical aspects and plasma insulin response pattern
Acta Med Scand
Insulin responses in equivocal and definite diabetes, with special reference to subjects who had mild glucose intolerance but later developed definite diabetes
Diabetes
Diminished insulin response to hyperglycemia in prediabetes and diabetes
Diabetes
Acute and steady-state insulin responses to glucose in nonobese diabetic subjects
J Clin Invest
Diabetes mellitus among the Navajo. II. Plasma glucose and insulin responses
Arch Intern Med
Study of the relationship between glucose and insulin responses to an oral glucose load in man
Diabetes
The plasma insulin response to glucose infusion in healthy subjects and in diabetes mellitus
Acta Endocrinol (Kobenhavn)
Serial postprandial plasma insulin levels in 117 subjects with and without diabetes
Diabetes
The significance of interpretation of mildly abnormal oral glucose tolerance
Diabetologia
Excessive serum insulin response to oral glucose in obesity and mild diabetes. Study of 501 patients
Diabetes
Insulin binding in diabetes. Relationships with plasma insulin levels and insulin sensitivity
Diabetes
Confirmation of impaired early insulin response to glycemic stimulus in nonobese mild diabetics
Diabetes
Comparison of plasma insulin levels following administration of tolbutamide and glucose
Diabetes
Glucose and insulin secretory response patterns following diet and tolazamide therapy in diabetes
Br Med J
Steady-state plasma insulin response to continuous glucose infusion in normal and diabetic subjects
Diabetes
Plasma insulin studies in two hundred patients with diabetes mellitus
Q J Med
Insulin response in glucose-tolerance tests
Am J Clin Pathol
Insulin excess as the initial lesion in diabetes
Lancet
Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion
Diabetes
Ethnic variability in glucose tolerance and insulin secretion
Arch Intern Med
The course of asymptomatic diabetes in young people as determined by levels of blood glucose and plasma insulin
Trans Assoc Am Physicians
Clinical and etiologic heterogeneity of idiopathic diabetes mellitus
Diabetes
Heterogeneity of insulin responses in latent diabetes
Trans Assoc Am Physicians
The various faces of diabetes in the young: changing concepts
Arch Intern Med
Secretion of insulin induced by amino acids and glucose in diabetes mellitus
J Clin Endocrinol
Early phase of insulin release
Diabetes
Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus
J Clin Invest
Plasma insulin concentrations in nondiabetic and early diabetic subjects. Determinations by a new selective immuno-assay technic
Diabetes
Ten-year follow-up of subjects with impaired glucose tolerance: prevention of diabetes by tolbutamide and diet regulation
Diabetes
Insulin patterns in equivocal glucose tolerance tests (chemical diabetes)
Diabetes
Is there a delay in the plasma insulin response of patients with chemical diabetes mellitus?
Diabetes
Insulin responses of children with chemical diabetes mellitus
N Engl J Med
Cited by (249)
Role of the kidney in normal glucose homeostasisand pathogenesis of type 2 diabetes: The list of culprits is still growing!
2013, Medecine des Maladies MetaboliquesFrom excess adiposity to insulin resistance: The role of free fatty acids
2012, Vascular PharmacologyCitation Excerpt :The most frequent pathologic condition associated with excess body fat and particularly with visceral obesity is known as the “Metabolic Syndrome” (MetS) (Avogaro et al., 1967; Kim and Reaven, 2004; Eckel et al., 2005; Reaven, 2005; Cornier et al., 2008; Giorgino, 2009), a constellation of symptoms, signs and pathophysiological conditions including visceral obesity, insulin resistance, impaired glucose metabolism and type 2 diabetes mellitus (DM), as well as atherogenic dyslipidemia, elevated blood pressure, and other comorbidities including a prothrombotic and proinflammatory state and nonalcoholic fatty liver disease. All these conditions independently increase the risk of atherosclerotic diseases, such as ischemic heart disease and stroke (DeFronzo et al., 1983; Ferrannini et al., 1983; Kelley et al., 1993; Berg and Scherer, 2005; Bays and Ballantyne, 2006; Schenk et al., 2008; Madonna and De Caterina, 2012). Among metabolic derangements induced by excess fat accumulation, insulin resistance appears to be the most important metabolic consequence of fat accumulation, leading in most cases to type 2 DM.
Medical Management of Patients with Diabetes Mellitus During the Perioperative Period
2008, Levin and O'Neal's: The Diabetic FootTreatment of type 2 diabetes: Revision of current therapeutical options and priorities
2007, Medicina ClinicaMedical Management of Patients with Diabetes Mellitus During the Perioperative Period
2007, Levin and O'Neal's The Diabetic Foot with CD-ROMDiabetes in Older Adults
2006, Clinical Diabetes
- ☆
The authors' work on the sulfonylurea agents was supported by a grant from The Upjohn Company, Kalamazoo, Michigan. Much of the original data concerning the pathogenesis of noninsulin-dependent diabetes mellitus was generated from grants from the National Institutes of Health (AM 24092) and the Juvenile Diabetes Association. The work of Dr. Ferrannini was supported by Public Health Service International Research Fellowship 1-F05-TW02716-01. Dr. Koivisto was the recipient of a grant from the Finnish Ministry of Education.
- 1
From the Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut.