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Molecular mechanisms of radiation carcinogenesis and the linear, non-threshold dose response model of radiation risk estimation

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Abstract 

Recent research in molecular radiation carcinogenesis is reviewed with the specific aim of exploring the implications this research may have on the dose response relationship of radiation-induced cancer at low doses and low dose rates. It is concluded that the linear non-threshold dose response hypothesis may be used in radiation protection planning as a simple, convenient method to optimize procedures and regulations, but should not be mistaken as a stringent scientific conclusion directly derived from the present state of knowledge of the processes involved in radiation carcinogenesis.

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Authors and Affiliations

  1. Department of Radiation Biology, St. Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary & Westfield College, Charterhouse Square, London, EC1M 6BQ, UK, , , , , , GB

    K. R. Trott

  2. GSF – National Research Center for Environment and Health, Institute of Pathology, Neuherberg, Germany, , , , , , DE

    M. Rosemann

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  1. K. R. Trott
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  2. M. Rosemann
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Received: 18 October 1999 / Accepted: 10 February 2000

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Trott, K., Rosemann, M. Molecular mechanisms of radiation carcinogenesis and the linear, non-threshold dose response model of radiation risk estimation. Radiat Environ Biophys 39, 79–87 (2000). https://doi.org/10.1007/s004110000047

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  • DOI: https://doi.org/10.1007/s004110000047

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