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The zoonotic potential of bovine leukemia virus

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Abstract

Many workers have investigated the possibility that bovine leukemia virus (BLV) might be transmissible to man. The epidemiological studies were designed to examine for associations between human leukemia and a rural environment, cattle farming, veterinary activities, or bovine leukosis. The serological studies were used to test serum samples from human cancer patients and from persons with potential occupational exposure to BLV, among others, for evidence of BLV antibodies. All these studies are critically reviewed. It is concluded that there is no epidemiological or serological evidence from human studies to indicate that BLV can infect man.

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References

  • Aleksandrowicz, J., 1968. Leukemia in humans and animals in the light of epidemiologic studies with reference to problems of its prevention. Acta Med. Polona, 9:217–230.

    Google Scholar 

  • Bartsch, D.C., Springher, F. and Falk, H., 1975. Acute nonlymphocytic leukemia: an adult cluster. J. Amer. Med. Assoc., 232:1333–1336.

    Google Scholar 

  • Blair, A. and Hayes, H.M., 1980. Cancer and other causes of death among U.S. veterinarians, 1966–1977. Int. J. Cancer, 25:181–185.

    PubMed  Google Scholar 

  • Blair, A. and Thomas, T.L., 1979. Leukemia among Nebraska farmers: a death certificate study. Amer. J. Epidemiol., 110:264–273.

    Google Scholar 

  • Botts, R.P., Edlavitch, S. and Payne, G., 1966. Mortality of Missouri veterinarians. J. Amer. Vet. Med. Assoc., 149:499–504.

    Google Scholar 

  • Burridge, M.J., 1979. Review of epidemiologic studies investigating possible association between bovine leukosis and human disease. In: Proceedings of Bovine Leukosis Symposium. U.S. Department of Agriculture, Washington, pp. 135–142.

    Google Scholar 

  • Caldwell, G.G., 1979. Bovine leukemia virus, public health serologic studies. In: Proceedings of Bovine Leukosis Symposium. U.S. Department of Agriculture, Washington, pp. 143–159.

    Google Scholar 

  • Caldwell, G.G., Baumgartener, L., Carter, C., Cotter, S., Currier, R., Essex, M., Hardy, W., Olson, C. and Olsen, R., 1976. Seroepidemiologic testing in man for evidence of antibodies to feline leukemia virus and bovine leukemia virus. Bibl. Haematol., 43:238–241.

    Google Scholar 

  • Clemmesen, J., Busk, T. and Neilsen, A., 1952. The topographical distribution of leukemia and Hodgkin's disease in Denmark 1942–46. Acta Radiol., 37:223–230.

    PubMed  Google Scholar 

  • de The, G., Geser, A., Day, N.E., Tukei, P.M., Williams, E.H., Beri, D.P., Smith, P.G., Dean, A.G., Bornkamm, G.W., Feorino, P. and Henle, W., 1978. Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study. Nature, 274:756–761.

    PubMed  Google Scholar 

  • Diglio, C.A. and Ferrer, J.F., 1976. Induction of syncytia by the bovine C-type leukemia virus. Cancer Res., 36:1056–1067.

    PubMed  Google Scholar 

  • Donham, K.J., Berg, J.W. and Sawin, R.S., 1980. Epidemiologic relationships of the bovine population and human leukemia in Iowa. Amer. J. Epidemiol., 112:80–92.

    Google Scholar 

  • Donham, K.J., Van Der Maaten, M.J., Miller, J.M., Kruse, B.C. and Rubino, M.J., 1977. Seroepidemiologic studies on the possible relationships of human and bovine leukemia: brief communication. J. Natl. Cancer Inst., 59:851–853.

    PubMed  Google Scholar 

  • Dutcher, R.M., Larkin, E.P. and Marshak, R.R., 1964. Virus-like particles in cow's milk from a herd with a high incidence of lymphosarcoma. J. Natl. Cancer Inst., 33:1055–1064.

    Google Scholar 

  • Fasal, E., Jackson, E.W. and Klauber, M.R., 1968. Mortality in California veterinarians. J. Chron. Dis., 19:293–306.

    Google Scholar 

  • Fasal, E., Jackson, E.W. and Klauber, M.R., 1968. Leukemia and lymphoma mortality and farm residence. Amer. J. Epidemiol., 87:267–274.

    Google Scholar 

  • Ferrer, J.F., 1980. Bovine lymphosarcoma. Adv. Vet. Sci. Comp. Med., 24:1–68.

    PubMed  Google Scholar 

  • Gilden, R.V., Long, C.W., Hanson, M., Toni, R., Charman, H.P., Oroszlan, S., Miller, J.M. and Van Der Maaten, M.J., 1975. Characteristics of the major internal protein and RNA-dependent DNA polymerase of bovine leukaemia virus. J. Gen. Virol, 29:305–314.

    PubMed  Google Scholar 

  • Githens, J.H., Elliot, F.E. and Saunders, L.H., 1965. The relation of socioeconomic factors to incidence of childhood leukemia. Public Health Rep., 80:573–578.

    PubMed  Google Scholar 

  • Heath, C.W., 1970. Human leukemia: genetic and environmental clusters. Bibl. Haematol., 36:649–653.

    PubMed  Google Scholar 

  • Heller, H. and Roubenoff, R., 1961. Malignant lymphoma and acute lymphatic leukaemia in people working in an East African meat-packing house. Lancet, 2:314–315.

    Google Scholar 

  • Henricson, B. and Ringertz, N., 1968. Comparative statistical studies on the geographical distribution of human and bovine leukemia in Sweden. Bibl. Haematol., 31:331–332.

    Google Scholar 

  • Jensen, N.K., 1968. A topographical study of leukemia in man and cattle in Denmark. Bibl. Haematol., 31:326–330.

    Google Scholar 

  • Khokhlova, M.P. and Rakhmanin, P.P., 1970. Comparative study on geographical distribution of human and cattle leukosis. Bibl. Haematol., 36: 654–658.

    PubMed  Google Scholar 

  • Knox, G., 1964. Epidemiology of childhood leukaemia in Northumberland and Durham. Brit. J. Prev. Soc. Med., 18:17–24.

    Google Scholar 

  • Kvarnfors, E., Henricson, B. and Hugoson, G., 1975. A statistical study on farm and village level on the possible relations between human leukaemia and bovine leukosis. Acta Vet. Scand., 16:163–169.

    PubMed  Google Scholar 

  • Lemon, H.M., 1964. Food-borne viruses and malignant hemopoietic diseases. Bact. Rev., 28:490–492.

    PubMed  Google Scholar 

  • Levin, M.L., Haenszel, W., Carroll, B.E., Gerhardt, P.R., Handy, V.H. and Ingraham, S.C., 1960. Cancer incidence in urban and rural areas of New York State. J. Natl. Cancer Inst., 24:1243–1257.

    PubMed  Google Scholar 

  • Linos, A., Kyle, R.A., Elveback, L.R. and Kurland, L.T., 1978. Leukemia in Olmsted County, Minnesota, 1965–1974. Mayo Clin. Proc., 53:714–718.

    PubMed  Google Scholar 

  • Linos, A., Kyle, R.A., O'Fallon, W.M. and Kurland, L.T., 1980. A casecontrol study of occupational exposures and leukemia. Int. J. Epidemiol., 9:131–135.

    PubMed  Google Scholar 

  • Mancuso, T.F., Macfarlane, E.M. and Porterfield, J.C., 1955. The distribution of cancer mortality in Ohio. Amer. J. Public Health, 45:58–70.

    PubMed  Google Scholar 

  • McClure, H.M., Keeling, M.E., Custer, R.P., Marshak, R.R., Abt, D.A. and Ferrer, J.F., 1974. Erythroleukemia in two infant chimpanzees fed milk from cows naturally infected with the bovine C-type virus. Cancer Res., 34:2745–2757.

    PubMed  Google Scholar 

  • Meadors, G.F., 1956. Epidemiology of leukemia. Public Health Rep., 71: 103–108.

    PubMed  Google Scholar 

  • Milham, S., 1971. Leukemia and multiple myeloma in farmers. Amer. J. Epidemiol., 94:307–310.

    Google Scholar 

  • Miller, J.M., Miller, L.D., Olson, C. and Gillette, K.G., 1969. Virus-like particles in phytohemagglutinin-stimulated lymphocyte cultures with reference to bovine lymphosarcoma. J. Natl. Cancer Inst., 43:1297–1305.

    PubMed  Google Scholar 

  • Mussgay, M. and Kaaden, O.-R., 1978. Progress in studies on the etiology and serologic diagnosis of enzootic bovine leukosis. Current Topics Microbiol. Immunol., 79:43–72.

    Google Scholar 

  • Nastac, E., Stolan, M. and Athanasiu, P., 1974. Investigation on serum antibodies to a virus (3053LB) isolated from the plasma of a leukemic cow, in milkers, cows with leukosis and apparently healthy cows. Rev. Roum. Virol., 25:53–59.

    PubMed  Google Scholar 

  • O'Conor, G.T., 1961. Malignant lymphoma in African children. II. A pathological entity. Cancer, 14:270–283.

    PubMed  Google Scholar 

  • Olson, C., 1974. Bovine lymphosarcoma (leukemia) — a synopsis. J. Amer. Vet. Med. Assoc., 165:630–632.

    Google Scholar 

  • Olson, C. and Baumgartener, L., 1975. lymphosarcoma (leukemia) of cattle. Bovine Pract., 10:15–22.

    Google Scholar 

  • Olson, C. and Driscoll, D.M., 1978. Bovine leukosis: investigation of risk for man. J. Amer. Vet. Med. Assoc., 173:1470–1472.

    Google Scholar 

  • Piper, C.E., Ferrer, J.F., Abt, D.A. and Marshak, R.R., 1979. Postnatal and prenatal transmission of the bovine leukemia virus under natural conditions. J. Natl. Cancer Inst., 62:165–168.

    PubMed  Google Scholar 

  • priester, W.A., Oleinick, A. and Conner, G.H., 1970. Bovine leukosis and human cancer. Lancet, 1:367–368.

    Google Scholar 

  • Ressang, A.A., 1977. De kans op infectie door het bovine leukemie virus bij de mens. Tijdschr. Diergeneeskd., 102:457–458.

    Google Scholar 

  • Schnurrenberger, P.R., Martin, R.J. and Walker, J.F., 1977. Mortality in Illinois veterinarians. J. Amer. Vet. Med. Assoc., 170:1071–1075.

    Google Scholar 

  • Stark, C.R. and Oleinick, A., 1966. Urban or rural residence and histologic type distribution in 21,000 childhood leukemia deaths in the United States, 1950–59. J. Natl. Cancer Inst., 37:369–379.

    PubMed  Google Scholar 

  • Stewart, A., Webb, J. and Hewitt, D., 1958. A survey of childhood malignancies. Brit. Med. J., 1:1495–1508.

    Google Scholar 

  • Trainin, Z., Meirom, R., Barnea, A. and Ungar-Waron, H., 1976. Common reactivity of bovine and human sera towards bovine lymphoid tumor cells. Bibl. Haematol., 43:232–234.

    Google Scholar 

  • Van Der Maaten, M.J. and Miller, J.M., 1976. Serological evidence of transmission of bovine leukemia virus to chimpanzees. Vet. Microbiol., 1:351–357.

    Google Scholar 

  • Van Der Maaten, M.J. and Miller, J.M., 1977. Current assessment of human health hazards associated with bovine leukemia virus. In: Origins of Human Cancer. Cold Spring Harbor Laboratory, pp. 1223–1234.

  • Wisniewski, D. and Weinreich, J., 1966. Lymphatische leukamie bei vater und sohn. Blut, 12:241–244.

    PubMed  Google Scholar 

  • Wolska, A., 1968. Human and bovine leukaemias. Lancet, 1:1155.

    Google Scholar 

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Burridge, M.J. The zoonotic potential of bovine leukemia virus. Vet Res Commun 5, 117–126 (1981). https://doi.org/10.1007/BF02214976

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