Summary
After the long-term exposure to cadmium chloride in drinking water, the Wistar rats developed peripheral polyneuropathy. The main lesion was of myelin degeneration. Ultrastructural examination of the roots and sciatic nerves revealed segmental demyelination beginning from the node of Ranvier. There was the active autophagocytosis of Schwann cells which contained a number of myelin remmants and dense bodies. There was, on the other hand, the evidence of remyclination with toxic damage, in which the thinner myelin sheaths and abnormal myelinations were observed with increase of Schwann cells containing rich ribosomes. Axoplasmic changes were minimal, but consisted of accumulation of glycogen particles which very often produced glycogenosomes in characteristic appearance with axoplasmal dysfunction.
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This work was supported a part by Grant-in-Aid of Education, Science and Culture, Ministry of Education, Japan
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Sato, K., Iwamasa, T., Tsuru, T. et al. An ultrastructural study of chronic cadmium chloride-induced neuropathy. Acta Neuropathol 41, 185–190 (1978). https://doi.org/10.1007/BF00690433
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DOI: https://doi.org/10.1007/BF00690433