Summary
The concentrations of benzene, toluene, ethylbenzene, and o-, m- and p-xylene were measured in venous blood samples collected from 13 non-smokers and 14 cigarette smokers. The blood samples were analysed by a purge and trap technique followed by gas chromatography/mass spectrometry/computer analysis. The above-mentioned volatile organic compounds (VOC) could be detected in measurable amounts in all blood samples. This finding seems to reflect the ubiquitous exposure of humans to these agents in the urban environment, in non-smokers as well as in smokers. Smokers were found to have significantly higher blood concentrations of benzene (median 547 ng/l) and toluene (median 2201 ng/l) than non-smokers (median 190 ng/l and 1141 ng/l, respectively). The concentrations of ethylbenzene and xylenes also tended to be higher in smokers when compared to non-smokers. The different concentrations of these compounds in the blood of non-smokers appear to reflect the common concentration pattern found in outdoor urban air as well as in indoor air and also seem to be influenced by the different blood/air partition coefficients of these compounds. The results indicate that smoking is associated with a significant additional exposure to VOC, in particular to benzene and toluene.
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References
Angerer J (1979) Occupational chronic exposure to organic solvents. VII. Metabolism of toluene in man. Int Arch Occup Environ Health 43:63–67
Antoine SR, DeLeon IR, O'Dell-Smith RM (1986), Environmentally significant volatile organic pollutants in human blood. Bull Environ Contam Toxicol 36:364–371
Apostoli P, Brugnone F, Perbellini L (1982) Biomonitoring of occupational toluene exposure. Int Arch Occup Environ Health 50:153–159
Berlin M (1985) Low level benzene exposure in Sweden: effect on blood elements and body burden of benzene. Am J Ind Med 7:365–373
Berlin M, Gage JC, Gullberg B, Hom S, Knutsson P, Eng C, Tunek A (1980) Breath concentration as an index of the health risk from benzene. Scan J Work Environ Health 6:104–111
Braier L, Levy A, Dror K, Pardo A (1981) Benzene in blood and phenol in urine in monitoring benzene exposure in industry. Am J Ind Med 2:119–123
Bruckmann P, Beier R, Krautscheid S (1983) Immissionsmessungen von Kohlenwasserstoffen in den Belastungsgebieten Rhein-Ruhr. Staub — Reinhalt Luft 43:404–410
Bruckmann P, Kersten W, Funke W, Balfanz E, König J, Theisen J, Ball M, Päpke X (1988) The occurrence of chlorinated and other organic trace compounds in urban air. Chemosphere 12:2363–2380
Elmenhorst H, Schultz CH (1968) Flüchtige Inhaltsstoffe des Tabakrauches. Beiträge zur Tabakforschung 4:90–123
Fiscrova-Bergerova V, Diaz ML (1986) Determination and prediction of tissue-gas partition coefficients. Int Arch Occup Environ Health 58:75–87
Fishbein L (1988a) Benzene: uses, occurrence and exposure. In: Fishbein L, O'Neill IK (eds) Environmental carcinogens — methods of analysis and exposure measurement, vol 10 — Benzene and alkylated benzenes. IARC Scientific Publications No. 85, pp 67–96. International Agency for Research on Cancer, Lyon
Fishbein L (1988b) Toluene: uses, occurrence and exposure. In: Fishbein L, O'Neill IK (eds) Environmental carcinogens — methods of analysis and exposure measurement, vol 10 — Benzene and alkylated benzenes. IARC Scientific Publications No. 85, pp 97–108. International Agency for Research on Cancer, Lyon
Fishbein L (1988c) Xylenes: uses, occurrence and exposure. In: Fishbein L, O'Neill IK (eds) Environmental carcinogens — methods of analysis and exposure measurement, vol 10 — Benzene and alkylated benzenes. IARC Scientific Publications No. 85, pp 109–120. International Agency for Research on Cancer, Lyon
Hartwell TD, Pellizzari ED, Perritt RL, Whitmore RW, Zelon HS, Sheldon LS, Sparacino CM (1987) Results from the total exposure assessment methodology (TEAM) study in selected communities in Northern and Southern California. Atmos Environ 21:1995–2004
IARC (International Agency for Research on Cancer) (1986) Tobacco smoking. IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol. 38. IARC, Lyon
Krause C, Mailahn W, Nagel R, Schulz C, Seifert B, Ullrich D (1987) Occurrence of volatile organic compounds in the air of 500 homes in the Federal Republic of Germany. Indoor air '87. Proc 4th Int Conf Indoor Air Quality and Climate, Berlin (West), 17–31 August 1987, vol 1, pp 102–106
Lauwerys RR (1983) Industrial chemical exposure: guidelines for biological monitoring. Biomedical Publications, Davis, CA
LIS (Landesanstalt für Immissionsschutz des Landes Nordrhein-Westfalen) (1988) Die Immissionsbelastung durch Benzol in Nordrhein-Westfalen. LIS-Berichte Nr. 82
Norpoth K, Stücker W, Krewet E, Müller G (1988) Biomonitoring of benzene exposure by trace analyses of phenylguanine. Int Arch Occup Environ Health 60:163–168
Perbellini L, Faccini GB, Pasini F, Cazzoli F, Pistoia S, Rosellini R, Valsecchi M, Brugnone F (1988) Environmental and occupational exposure to benzene by analysis of breath and blood. Br J Ind Med 45:345–352
Sato A (1988) Toxicokinetics of benzene, toluene and xylenes. In: Fishbein L, O'Neill IK (eds) Environmental carcinogens — methods of analysis and exposure measurement, vol 10 — Benzene and alkylated benzenes. IARC Scientific Publications No. 85, pp 47–64. International Agency for Research on Cancer, Lyon (France)
Sato A, Nakajima T (1979) Partition coefficients of some hydrocarbons and ketones in water, blood and oil. Br J Ind Med 36:231–234
Seifert B, Ulrich D, Mailahn W, Nagel R (1986) Flüchtige organische Verbindungen in der Innenraumluft. Bundesgesundheitsblatt 29:417–424
Sherwood RJ (1972) Benzene: The interpretation of monitoring results. Ann Occup Hyg 15:409–421
Sherwood R (1976) Ostwald solubility coefficients of some industrial important substances. Br J Ind Med 33:106–107
Szadkowski D, Pett R, Angerer J, Manz A, Lehnert G (1973) Chronische Lösungsmittelbelastung am Arbeitsplatz. II. Schadstoffspiegel im Blut und Metabolitenelimination im Harn und ihre Bedeutung als Überwachungskriterien bei toluolexponierten Tiefdruckern. Int Arch Arbeitsmed 31:265–276
Wallace LA, Pellizzari ED (1986) Personal air exposure and breath concentrations of benzene and other volatile hydrocarbons for smokers and non-smokers. Toxicol Lett 35:113–116
Wallace LA, Pellizzari ED, Hartwell TD, Sparacino CM, Sheldon LS, Zelon H (1985) Personal exposures, indoor-outdoor relationships, and breath levels of toxic air pollutants measured for 355 persons in New Jersey. Atmos Environ 19:1651–1661
Wallace L, Pellizzari E, Hartwell T, Zelon H, Sparacino C, Perritt R, Whitmore R (1986) Concentrations of 20 volatile organic compounds in the air and drinking water of 350 residents of New Jersey compared with concentrations in their exhaled breath. J Occup Med 28:603–60
Wallace L, Pellizzari E, Leaderer B, Zelon H, Sheldon L (1987) Emissions of volatile organic compounds from building materials and consumer products. Atmos Environ 21:385–393
WHO (1985) Toluene. Environmental health criteria 52. World Health Organization, Geneva
WHO-Euro (= WHO Regional Office for Europe) (1987) Air quality guidelines for Europe. WHO Regional Publications, European Series No. 23
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Hajimiragha, H., Ewers, U., Brockhaus, A. et al. Levels of benzene and other volatile aromatic compounds in the blood of non-smokers and smokers. Int. Arch Occup Environ Heath 61, 513–518 (1989). https://doi.org/10.1007/BF00683121
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DOI: https://doi.org/10.1007/BF00683121