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Smoking and dietary intake of polycyclic aromatic hydrocarbons as sources of interindividual variability in the baseline excretion of 1-hydroxypyrene in urine

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Summary

Seventy-six male volunteers, who were not occupationally exposed to polycyclic aromatic hydrocarbons (PAHs), participated in a study on the effect of tobacco smoking, alcohol consumption, dietary PAH intake, age, and body fat content on the baseline excretion of 1-hydroxypyrene in urine. Major determinants of urinary 1-hydroxypyrene excretion were smoking, dietary PAH intake, and age. The mean 1-hydroxypyrene concentrations in the urine of the volunteers in this study ranged between 0.05 and 0.79 μmol/mol creatinine. Smokers excreted on average 0.25 μmol/mol creatinine (range: 0.10–0.79 μmol/mol creatinine), and nonsmokers on average 0.12 μmol/mol creatinine (range: 0.04–0.29 μmol/mol creatinine). The average number of cigarettes smoked per day correlated well with urinary 1-hydroxypyrene concentrations (r s = 0.67, P < 0.001). The consumption of PAH-containing food products and active smoking account for 99% of total pyrene intake. The effect of age on 1-hydroxypyrene excretion is probably caused by a lower creatinine excretion in the elderly. Passive smoking and fat content had a statistically significant, but negligible effect on urinary 1-hydroxypyrene excretion. Passive smoking and the inhalation of ambient air are relatively inimportant for total pyrene intake (both account for less than 1%). Neither the consumption of alcohol nor the inhalation of ambient air significantly affected urinary 1-hydroxypyrene excretion. It is concluded that when urinary 1-OH-pyrene excretion is used in the assessment of PAH exposure, one should particularly be aware of the interindividual variability of the baseline excretion of PAH metabolites due to tobacco smoking and dietary PAH intake.

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Authors and Affiliations

  1. Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, P. O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands

    Joost G. M. Van Rooij, Mirjam M. S. Veeger, Monika M. Bodelier-Bade & Paul T. J. Scheepers

  2. Indus Tox Consult, P. O. Box 31070, NL-6503 CB, Nijmegen, The Netherlands

    Frans J. Jongeneelen

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  1. Joost G. M. Van Rooij
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  2. Mirjam M. S. Veeger
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  3. Monika M. Bodelier-Bade
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  4. Paul T. J. Scheepers
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  5. Frans J. Jongeneelen
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Van Rooij, J.G.M., Veeger, M.M.S., Bodelier-Bade, M.M. et al. Smoking and dietary intake of polycyclic aromatic hydrocarbons as sources of interindividual variability in the baseline excretion of 1-hydroxypyrene in urine. Int. Arch Occup Environ Heath 66, 55–65 (1994). https://doi.org/10.1007/BF00386580

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