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Urinary cyclophosphamide assay as a method for biological monitoring of occupational exposure to cyclophosphamide

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Summary

Urine of twenty hospital workers was monitored for the excretion of the cytostatic drug cyclophosphamide using GC-MSD. The drug was found to be present above the detection limit of 0.5 μg/24 h urine in five cases. A clear relationship between cyclophosphamide handling and the detectability of excretion existed. This method developed can be of use for biological monitoring studies directed toward the finding of exposure hazards.

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Evelo, C.T.A., Bos, R.P., Peters, J.G.P. et al. Urinary cyclophosphamide assay as a method for biological monitoring of occupational exposure to cyclophosphamide. Int Arch Occup Environ Health 58, 151–155 (1986). https://doi.org/10.1007/BF00380766

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  • DOI: https://doi.org/10.1007/BF00380766

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