Abstract
The incidence of childhood malignancies in 20 areas surrounding major nuclear installations is compared with the incidence in matched control regions. The study is based on the registry of childhood malignancies in the Federal Republic of Germany and includes 1,610 cases which were diagnosed before 15 years of age from 1980 to 1990. The relative risk (RR) was 0.97 for all malignancies and 1.06 for acute leukemia in all regions within a 15 km radius of an installation. Increased RR was observed in subgroups for acute leukemia before five years of age and for lymphomas, especially in regions close to installations (<5 km) which started operation before 1970. Most of this increase was attributable to an unexpectedly low incidence in the control regions which could not be explained by analyzing possible confounding factors. Using the same control regions, a comparable and even more pronounced increase of RRs was observed in regions where nuclear power plants have been projected.
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Report of the Independent Advisory Group. Investigation of the possible increased incidence of cancer in West Cumbria. Chairman: Sir Douglas Black. London: HM Stationery Office, 1984.
Gardner MJ, Winder PD. Cancer in Cumberland during 1959–68 with reference to cancer in young people around Windscale. Lancet 1984; i: 216–7.
Baron JA. Cancer mortality in small areas around nuclear facilities in England and Wales. Br J Cancer 1984; 50: 815–24.
Heasman MA, Kemp IW, Urquhart JD, Black R. Childhood leukemia in northern Scotland. Lancet 1986; i: 266.
Cook-Mozaffari PJ, Ashwood FL, Vincent T, Forman D, Alderson M. Cancer Incidence and Mortality in the Vicinity of Nuclear Installations. England and Wales 1950–1980, London: HM Stationery Office, 1987.
Forman D, Cook-Mozaffari P, Darby S, et al. Cancer near nuclear installations. Nature 1987; 329: 499–505.
Barton CJ, Roman E, Ryder HM, Watson A. Childhood leukaemia in West Berkshire. Lancet 1985; ii: 1248–9.
Hill C, Laplanche A. Overall mortality and cancer mortality around French nuclear sites. Nature 1990; 347: 755–7.
Viel JF, Richardson ST. Childhood leukaemia around the La Hague nuclear waste reprocessing plant. Br Med J 1990; 300: 580–1.
Crump KS, Ng TH, Cuddihy RG. Cancer incidence patterns in the Denver metropolitan area in relation to the Rocky Flats plant. Am J Epid 1987; 126: 127–35.
Hatch MC, Beyea J, Nieves JW, Susser M. Cancer near the Three Mile Island nuclear plant: radiation emissions. Am J Epid 1990; 132: 397–417.
Jablon S, Hrubec Z, Boice JD. Cancer in populations living near nuclear facilities. A survey of mortality nation wide and incidence in two states. JAMA 1991; 265: 1403–8.
Clarke EA, McLaughlin J, Anderson TW. Childhood Leukemia Around Canadian Nuclear Facilities—phase Il final report. Ottawa: Atomic Energy Control Board Report, 1991.
Wakeford R. Some problems in the interpretation of childhood cancer clusters. In: Thomas RW, ed. Spatial Epidemiology. London: Pion, 1990.
Gardner MJ, Snee MP, Hall AJ, Powell CA, Downes S, Terrell JD. Results of case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. Br Med J 1990; 300: 423–9.
Urquhart JD, Black RJ, Muirhead MJ, et al. Case-control study of leukaemia and non-Hodgkin's lymphoma in children in Caithness near the Dounreay nuclear installation. Br Med J 1991; 302: 687–92.
Kinlen L. Evidence for an infective cause of childhood leukaemia: Comparison of a Scottish new town with nuclear reprocessing sites in Britain. Lancet 1988; ii: 1323–6.
Cook-Mozaffari P, Darby S, Doll R. Cancer near potential sites of nuclear installations. Lancet 1989; ii: 1145–7.
Informationen zur Raumentwicklung. Aktuelle Daten und Prognosen zur Räumlichen Entwicklung. BfLR—Bundesforschungsanstalt für Landeskunde und Raumordnung. Bonn: Heft 11/12, 1987.
Keller B, Haaf G, Kaatsch P, Michaelis J. Untersuchung der Häufigkeit von Krebserkrankungen im Kindesalter in der Umgebung Westdeutscher Kerntechnischer Anlagen. Mainz: IMSD—Technischer Bericht, 1992.
Cook-Mozaffari PJ, Darby SC, Doll R, et al. Geographical variation in mortality from leukaemia and other cancers in England and Wales in relation to proximity to nuclear installations, 1969–1978. Br J Cancer 1989; 59: 476–85.
Lehmann EL. Testing Statistical Hypotheses. New York: John Wiley & Sons, Inc., 1986.
Haaf G, Kaatsch P, Keller B, Michaelis J. Jahresbericht 1990 des Kinderkrebsregisters Mainz. Mainz: IMSD—Technischer Bericht, 1991.
Bericht über Umweltradioaktivität und Strahlenbelastung. Bonn: Bundesminister für Umwelt, Naturschutz und Reaktorsicherheit, annual reports.
Draper G, ed. The Geographical Epidemiology of Childhood leukaemia and Non-Hodgkin Lymphomas in Great Britain, 1966–83. London: HM Stationery Office, 1991.
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Address correspondence to Dr Michaelis. This research was supported by the Bundesministerium für Umwelt, Naturschutz und Reaktorsicherheit.
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Michaelis, J., Keller, B., Haaf, G. et al. Incidence of childhood malignancies in the vicinity of West German nuclear power plants. Cancer Causes Control 3, 255–263 (1992). https://doi.org/10.1007/BF00124259
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DOI: https://doi.org/10.1007/BF00124259