Regular ArticleConstitutive Expression of Metallothionein-III (MT-III), but Not MT-I, Inhibits Growth When Cells Become Zinc Deficient
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Regulation of matrix metalloproteinase-9 during monopoiesis and zinc deficiency by chromatin remodeling
2023, Journal of Trace Elements in Medicine and BiologyExposure to low level of lead during preweaning period increases metallothionein-3 expression and dysregulates divalent cation levels in the brain of young rats
2018, NeuroToxicologyCitation Excerpt :It is an essential component of or a cofactor for many metalloenzymes and transcription factors and thus it regulates the transcription of specific genes (McCall et al., 2000). Zn is released at glutamatergic synapses in response to depolarization and acts through the ionotropic glutamate receptors (Palmiter, 1995). Neuronal response to Zn depends on its concentration and the receptor subtype.
Metallothionein and Intracellular Sequestration of Metals
2018, Comprehensive Toxicology: Third EditionMetallothionein and Intracellular Sequestration of Metals
2010, Comprehensive Toxicology, Second EditionMutation at Glu23 eliminates the neuron growth inhibitory activity of human metallothionein-3
2006, Biochemical and Biophysical Research CommunicationsCitation Excerpt :The results show that both of the fast and slow rate constants are very similar and it can be concluded that stability of the metal–thiolate clusters of the E23K mutant is not altered much. In the earlier biological studies on hMT3, specific structural properties of the protein or an altered zinc affinity for hMT3 compared to those of other MTs have been considered as a possible reason for the observed biological activity [16,17]. However, according to the results of pH titration and EDTA reaction, the difference in the zinc binding affinity is rather small, indicating the metal–thiolate clusters of the E23K mutant are comparable to those of hMT3.