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The Use of Nasal Lavage for Objective Measurement of Irritant-Induced Nasal Inflammation

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Cited by (23)

  • Overview on the occurrence of microplastics in air and implications from the use of face masks during the COVID-19 pandemic

    2021, Science of the Total Environment
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    Nasal lavages is a simple technique which allows the measurement of the irritation response to the particles deposited on the mucosal surface. Normally, medical biomarkers are measured after the lavage such as inflammatory cell influx, eicosanoid mediators, neuropeptide release, or nasal glandular products (Peden, 1996). Previous works report satisfactory results using nasal lavages on different fields: measurement the effect of allergens (Kaliner and Lemanske, 1992), tools to control air quality (Norbäck et al., 2000) or assessment of inflammations produced by ozone or volatile organic compounds (VOCs) (Laumbach et al., 2005).

  • Nasal lavages as a tool for monitoring exposure to organic pollutants

    2019, Environmental Research
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    The levels of eosinophil cationic protein, myeloperoxidase, lysozyme and albumin in nasal lavages of children were good indicators of indoor air quality in schools and used to comply ventilation standards (Norback et al., 2000). Nasal lavages served also as a sensitive and reliable procedure to detect inflammation in the upper airways of subjects exposed to ozone (Peden, 1996), to VOCs (Koren et al., 1992) or inhaled pollutants and dust allergens which can exert a chronic damage to lung function (Koren et al., 1992). Whereas nasal lavages are used in medicine to detect inflammatory responses associated to air quality, their use to determine pollutant uptake through inhalation has not been attempted.

  • Circulating neutrophil CD14 expression and the inverse association of ambient particulate matter on lung function in asthmatic children

    2007, Annals of Allergy, Asthma and Immunology
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    The EBC fluid was collected using a standardized field method (R-Tube; Respiratory Research Inc, Charlottesville, Virginia) and subsequently analyzed for acidity.27,28 Nasal lavage was performed using a previously described method, 29-31 and collected samples were analyzed for differential cell counts. The study-specific air monitoring methods and the validation study have been previously reported elsewhere.32

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