Fundamental and Applied Toxicology
Regular ArticleRespiratory Allergenicity of Detergent Enzymes in the Guinea Pig Intratracheal Test: Association with Sensitization of Occupationally Exposed Individuals☆
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Impact strength distribution of placebo enzyme granules
2015, Powder TechnologyCitation Excerpt :The current enzyme granule manufacturing produces strong granules; however, a very small number of them are weak, and prone to breakage. The protein dust (particles smaller than 100 μm) can potentially cause respiratory allergy and asthma, as investigated in the late 1960's by Pepys et al. [2] and Flindt [3], and the effects of the enzyme dust on the workers in a detergent manufacturing plant have been reported by Sarlo et al. [4] and Vanhanen et al. [5]. Hence, it is very important for manufacturing to examine the dustiness and strength of the enzyme granules.
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2014, Applied Dermatotoxicology: Clinical AspectsEnzymes in cleaning products: An overview of toxicological properties and risk assessment/management
2012, Regulatory Toxicology and PharmacologyCitation Excerpt :In contradistinction to the situation with skin, exposure of the respiratory tract to enzyme proteins does have the potential to progress beyond a normal immune response and to give rise to the production of antigen specific IgE. Although there is published evidence that enzymes can drive the formation of anaphylactic IgE antibodies in animal models (Sarlo et al., 1997; Robinson et al., 1998; Basketter et al., 2012a), the most critical information derives from human experience. It is well known that sufficient exposure can lead to the clinical symptoms of allergy including asthma.
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2004, Immunotoxicology of Drugs and Chemicals: an Experimental and Clinical ApproachControl of occupational asthma and allergy in the detergent industry
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This work was funded by the Procter & Gamble Co. (Cincinnati, OH).
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