Table 3

Cumulative exposure to asbestos and risk of intrahepatic cholangiocarcinoma: comparison of unlagged/lagged exposure metrics

Lag period	Cases (n=1458)	Controls (n=6773)	OR (95% CI)	p trend	BIC
No lag				0.004	5036.3
0 f/mL × years	1171	5548	1.0 (Ref)
0.1–1.1 f/mL × years	144	641	1.2 (1.0 to 1.4)
1.2–14.9 f/mL × years	109	480	1.2 (1.0 to 1.5)
≥15.0 f/mL × years	34	104	1.7 (1.1 to 2.6)
10-year lag				0.006	5037.6
0 f/mL × years	1177	5564	1.0 (Ref)
0.1–1.1 f/mL × years	143	641	1.2 (0.9 to 1.4)
1.2–14.9 f/mL × years	108	474	1.2 (1.0 to 1.5)
≥15.0 f/mL × years	30	94	1.7 (1.1 to 2.6)
20-year lag				0.003	5035.4
0 f/mL × years	1196	5663	1.0 (Ref)
0.1–1.1 f/mL × years	133	586	1.2 (1.0 to 1.5)
1.2–14.9 f/mL × years	110	477	1.2 (1.0 to 1.5)
≥15.0 f/mL × years	19	47	2.1 (1.2 to 3.7)
30-year lag				0.023	5040.3
0 f/mL × years	1259	5923	1.00 (Ref)
0.1–1.1 f/mL × years	102	454	1.2 (0.9 to 1.5)
1.2–14.9 f/mL × years	94	389	1.3 (1.0 to 1.6)
≥15.0 f/mL × years	3	7	2.3 (0.6 to 8.8)

Estimates from logistic regression models conditioned on matching variables (year of birth, gender and country).
BIC, Bayesian information criterion; Ref, reference category.